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Interactions between compounds and specific gene/protein targets.
| BIMP_ID | Target Name | Gene | Organism | Action | Source URL |
|---|---|---|---|---|---|
|
Abcb1a
|
Rattus norvegicus (Norway rat)
|
Verapamil results in decreased expression of ABCB1A mRNA
|
https://ctdbase.org/detail.go?type=gene&acc=18671
|
||
|
Abcb1a
|
Mus musculus (house mouse)
|
Benzo(a)pyrene results in decreased expression of ABCB1A mRNA
|
https://ctdbase.org/detail.go?type=gene&acc=18671
|
||
|
Abcb1a
|
Mus musculus (house mouse)
|
Chloroquine promotes the reaction [bortezomib results in decreased expression of and results in increased nitrosation of ABCB1A protein]|cebpb protein alternative form promotes the reaction [[chloroquine co-treated with bortezomib] results in decreased expression of ABCB1A protein]|chloroquine results in decreased expression of and results in increased nitrosation of ABCB1A protein|chloroquine results in decreased expression of ABCB1A mrna|bortezomib promotes the reaction [chloroquine results in decreased expression of ABCB1A mrna]|chloroquine promotes the reaction [bortezomib results in decreased expression of ABCB1A mrna]|[chloroquine co-treated with bortezomib] results in decreased expression of ABCB1A protein|bortezomib promotes the reaction [chloroquine results in decreased expression of and results in increased nitrosation of ABCB1A protein]|doxorubicin promotes the reaction [CEBPB protein alternative form promotes the reaction [[chloroquine co-treated with bortezomib] results in decreased expression of ABCB1A protein]]
|
https://ctdbase.org/detail.go?type=gene&acc=18671
|
||
|
Abcb1a
|
Rattus norvegicus (Norway rat)
|
Berberine results in increased expression of ABCB1A mRNA
|
https://ctdbase.org/detail.go?type=gene&acc=18671
|
||
|
Abcb1a
|
Rattus norvegicus (Norway rat)
|
Nevirapine results in increased expression of ABCB1A mRNA
|
https://ctdbase.org/detail.go?type=gene&acc=18671
|
||
|
Abcb1a
|
Mus musculus (house mouse)
|
ABCB1A gene mutant form affects the transport of and results in increased abundance of huperzine A
|
https://ctdbase.org/detail.go?type=gene&acc=18671
|
||
|
Abcb1a
|
Mus musculus (house mouse)
|
ABCB1A protein results in increased transport of nortriptyline metabolite|abcb1a protein results in increased transport of nortriptyline
|
https://ctdbase.org/detail.go?type=gene&acc=18671
|
||
|
Abcb1a
|
Rattus norvegicus (Norway rat)
|
6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [vitamin A results in decreased expression of ABCB1A mrna]|mannitol inhibits the reaction [vitamin A results in decreased expression of ABCB1A mrna]|vitamin A results in decreased expression of ABCB1A mRNA
|
https://ctdbase.org/detail.go?type=gene&acc=18671
|
||
|
Abcb1a
|
Mus musculus (house mouse)
|
ABCB1A protein affects the susceptibility to loratadine
|
https://ctdbase.org/detail.go?type=gene&acc=18671
|
||
|
Abcb1a
|
Mus musculus (house mouse)
|
Isoproterenol results in increased expression of ABCB1A mRNA
|
https://ctdbase.org/detail.go?type=gene&acc=18671
|
||
|
Abcb1a
|
Mus musculus (house mouse)
|
ABCB1A protein affects the susceptibility to hypaconitine
|
https://ctdbase.org/detail.go?type=gene&acc=18671
|
||
|
Abcb1a
|
Mus musculus (house mouse)
|
ABCB1A protein affects the susceptibility to quinidine
|
https://ctdbase.org/detail.go?type=gene&acc=18671
|
||
|
Abcb1a
|
Mus musculus (house mouse)
|
Notoginsenoside R1 results in increased expression of ABCB1A mRNA
|
https://ctdbase.org/detail.go?type=gene&acc=18671
|
||
|
Abcb1a
|
Rattus norvegicus (Norway rat)
|
Ochratoxin A results in decreased expression of ABCB1A mRNA
|
https://ctdbase.org/detail.go?type=gene&acc=18671
|
||
|
Abcb1a
|
Rattus norvegicus (Norway rat)
|
6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [vitamin A results in decreased expression of ABCB1A mrna]
|
https://ctdbase.org/detail.go?type=gene&acc=18671
|
||
|
Abcb1a
|
Rattus norvegicus (Norway rat)
|
6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid results in decreased expression of ABCB1A protein
|
https://ctdbase.org/detail.go?type=gene&acc=18671
|
||
|
Abcb1a
|
Rattus norvegicus (Norway rat)
|
ABCB1A protein affects the susceptibility to puromycin|puromycin results in increased expression of ABCB1A protein|puromycin results in increased expression of ABCB1A mRNA
|
https://ctdbase.org/detail.go?type=gene&acc=18671
|
||
|
Abcb1a
|
Cricetulus griseus (Chinese hamster)
|
Mitotane inhibits the reaction [ABCB1A protein results in decreased susceptibility to daunorubicin]|mitotane inhibits the reaction [ABCB1A protein results in decreased susceptibility to dactinomycin]|mitotane inhibits the reaction [ABCB1A protein results in decreased susceptibility to thapsigargin]
|
https://ctdbase.org/detail.go?type=gene&acc=18671
|
||
|
Abcb1a
|
Mus musculus (house mouse)
|
PPARA promotes the reaction [clofibrate results in increased expression of ABCB1A protein]|clofibrate results in increased expression of ABCB1A mrna|clofibrate results in increased expression of ABCB1A protein|ppara promotes the reaction [clofibrate results in increased expression of ABCB1A mrna]
|
https://ctdbase.org/detail.go?type=gene&acc=18671
|
||
|
Abcb1a
|
Rattus norvegicus (Norway rat)
|
Clofibrate affects the expression of ABCB1A mRNA
|
https://ctdbase.org/detail.go?type=gene&acc=18671
|
||
|
Abcb1a
|
Mus musculus (house mouse)
|
Ciprofibrate results in increased expression of ABCB1A mRNA
|
https://ctdbase.org/detail.go?type=gene&acc=18671
|
||
|
Abcb1a
|
Mus musculus (house mouse)
|
ABCB1A protein affects the uptake of digoxin
|
https://ctdbase.org/detail.go?type=gene&acc=18671
|
||
|
Abcb1a
|
Rattus norvegicus (Norway rat)
|
ABCB1A protein results in increased uptake of digoxin
|
https://ctdbase.org/detail.go?type=gene&acc=18671
|
||
|
Abcb1a
|
Mus musculus (house mouse)
|
LEPR gene mutant form affects the reaction [[methionine deficiency co-treated with choline deficiency] results in increased expression of ABCB1A mrna]|[methionine deficiency co-treated with choline deficiency] results in increased expression of ABCB1A mrna|[lepr gene mutant form co-treated with methionine deficiency co-treated with choline deficiency] results in increased expression of ABCB1A protein
|
https://ctdbase.org/detail.go?type=gene&acc=18671
|
||
|
Abcb1a
|
Mus musculus (house mouse)
|
Clotrimazole inhibits the reaction [ABCB1A protein results in increased secretion of fluorexon]
|
https://ctdbase.org/detail.go?type=gene&acc=18671
|
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