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Interactions between compounds and specific gene/protein targets.
| BIMP_ID | Target Name | Gene | Organism | Action | Source URL |
|---|---|---|---|---|---|
|
ABCB1
|
Homo sapiens (human)
|
Nobiletin inhibits the reaction [ABCB1 protein results in increased transport of digoxin]
|
https://ctdbase.org/detail.go?type=gene&acc=5243
|
||
|
ABCB1
|
Homo sapiens (human)
|
Nobiletin promotes the reaction [ABCB1 protein results in increased hydrolysis of adenosine triphosphate]|nobiletin promotes the reaction [ABCB1 protein results in increased import of daunorubicin]
|
https://ctdbase.org/detail.go?type=gene&acc=5243
|
||
|
ABCB1
|
Homo sapiens (human)
|
2-methylindole results in increased expression of ABCB1 mRNA
|
https://ctdbase.org/detail.go?type=gene&acc=5243
|
||
|
ABCB1
|
Homo sapiens (human)
|
Tryptanthrine results in decreased expression of ABCB1 mrna|tryptanthrine binds to ABCB1 promoter|tryptanthrine results in decreased expression of ABCB1 protein
|
https://ctdbase.org/detail.go?type=gene&acc=5243
|
||
|
ABCB1
|
Homo sapiens (human)
|
|
https://www.dgidb.org/genes/hgnc:40
|
||
|
ABCB1
|
Homo sapiens (human)
|
Formaldehyde results in increased expression of ABCB1 mRNA
|
https://ctdbase.org/detail.go?type=gene&acc=5243
|
||
|
ABCB1
|
Homo sapiens (human)
|
|
https://www.dgidb.org/genes/hgnc:40
|
||
|
ABCB1
|
Homo sapiens (human)
|
|
https://www.dgidb.org/genes/hgnc:40
|
||
|
ABCB1
|
Homo sapiens (human)
|
ABCB1 gene polymorphism affects the reaction [dexamethasone results in decreased secretion of IFNG protein]|abcb1 gene polymorphism affects the susceptibility to dexamethasone|abcb1 gene polymorphism affects the reaction [dexamethasone results in decreased secretion of IL4 protein]|abcb1 gene polymorphism affects the reaction [dexamethasone results in decreased secretion of IL2 protein]|abcb1 gene polymorphism affects the reaction [dexamethasone results in decreased secretion of TNF protein]
|
https://ctdbase.org/detail.go?type=gene&acc=5243
|
||
|
ABCB1
|
Homo sapiens (human)
|
Valspodar inhibits the reaction [ABCB1 protein results in increased secretion of dexamethasone]|abcb1 protein results in increased secretion of dexamethasone|elacridar inhibits the reaction [ABCB1 protein results in increased secretion of dexamethasone]
|
https://ctdbase.org/detail.go?type=gene&acc=5243
|
||
|
ABCB1
|
Homo sapiens (human)
|
Dexamethasone results in decreased activity of ABCB1 protein|dexamethasone results in increased expression of ABCB1 mRNA
|
https://ctdbase.org/detail.go?type=gene&acc=5243
|
||
|
ABCB1
|
Homo sapiens (human)
|
[tacrolimus results in decreased activity of ABCB1 protein] which results in decreased export of dexamethasone
|
https://ctdbase.org/detail.go?type=gene&acc=5243
|
||
|
ABCB1
|
Oryctolagus cuniculus (rabbit)
|
Dexamethasone results in increased expression of ABCB1 mRNA
|
https://ctdbase.org/detail.go?type=gene&acc=5243
|
||
|
ABCB1
|
Rattus norvegicus (Norway rat)
|
Dexamethasone results in decreased expression of ABCB1 mRNA
|
https://ctdbase.org/detail.go?type=gene&acc=5243
|
||
|
ABCB1
|
Rattus norvegicus (Norway rat)
|
Dexamethasone results in increased expression of ABCB1 protein
|
https://ctdbase.org/detail.go?type=gene&acc=5243
|
||
|
ABCB1
|
Homo sapiens (human)
|
Dactinomycin inhibits the reaction [estradiol results in increased expression of ABCB1 protein]|dactinomycin inhibits the reaction [estradiol results in increased expression of ABCB1 mrna]
|
https://ctdbase.org/detail.go?type=gene&acc=5243
|
||
|
ABCB1
|
Homo sapiens (human)
|
EGF protein promotes the reaction [estradiol results in decreased expression of ABCB1 mrna]|estradiol results in decreased expression of ABCB1 mRNA
|
https://ctdbase.org/detail.go?type=gene&acc=5243
|
||
|
ABCB1
|
Homo sapiens (human)
|
Tamoxifen inhibits the reaction [estradiol results in decreased expression of ABCB1 protein]|esr1 protein affects the reaction [estradiol results in decreased expression of ABCB1 protein]|[estradiol results in decreased expression of ABCB1 protein] which results in increased uptake of and results in increased susceptibility to vincristine
|
https://ctdbase.org/detail.go?type=gene&acc=5243
|
||
|
ABCB1
|
Homo sapiens (human)
|
Estradiol results in increased expression of ABCB1 mRNA
|
https://ctdbase.org/detail.go?type=gene&acc=5243
|
||
|
ABCB1
|
Homo sapiens (human)
|
Estradiol results in increased expression of ABCB1 protein
|
https://ctdbase.org/detail.go?type=gene&acc=5243
|
||
|
ABCB1
|
Mytilus galloprovincialis (Mediterranean mussel)
|
Estradiol results in increased expression of ABCB1 mRNA
|
https://ctdbase.org/detail.go?type=gene&acc=5243
|
||
|
ABCB1
|
Homo sapiens (human)
|
|
https://www.dgidb.org/genes/hgnc:40
|
||
|
ABCB1
|
Homo sapiens (human)
|
Mitomycin results in increased expression of ABCB1 protein
|
https://ctdbase.org/detail.go?type=gene&acc=5243
|
||
|
ABCB1
|
Bos taurus (cattle)
|
[valspodar results in decreased activity of ABCB1 protein] promotes the reaction [mitotane results in decreased secretion of hydrocortisone]|[valspodar results in decreased activity of ABCB1 protein] promotes the reaction [doxorubicin results in decreased secretion of hydrocortisone]
|
https://ctdbase.org/detail.go?type=gene&acc=5243
|
||
|
ABCB1
|
Homo sapiens (human)
|
Elacridar inhibits the reaction [ABCB1 protein results in increased secretion of hydrocortisone]|valspodar inhibits the reaction [ABCB1 protein results in increased secretion of hydrocortisone]|abcb1 protein results in increased secretion of hydrocortisone
|
https://ctdbase.org/detail.go?type=gene&acc=5243
|
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