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Interactions between compounds and specific gene/protein targets.
| BIMP_ID | Target Name | Gene | Organism | Action | Source URL |
|---|---|---|---|---|---|
|
ABCG2
|
Homo sapiens (human)
|
Lapatinib promotes the reaction [ABCG2 protein results in increased hydrolysis of adenosine triphosphate]|abcg2 protein results in increased hydrolysis of adenosine triphosphate
|
https://ctdbase.org/detail.go?type=gene&acc=9429
|
||
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ABCG2
|
Homo sapiens (human)
|
[adenosine triphosphate co-treated with ABCG2 protein] results in increased uptake of estrone sulfate|sulfasalazine inhibits the reaction [[adenosine triphosphate co-treated with ABCG2 protein] results in increased uptake of estrone sulfate]
|
https://ctdbase.org/detail.go?type=gene&acc=9429
|
||
|
ABCG2
|
Homo sapiens (human)
|
Sulfasalazine promotes the reaction [ABCG2 protein results in increased hydrolysis of adenosine triphosphate]|vanadates inhibits the reaction [sulfasalazine promotes the reaction [ABCG2 protein results in increased hydrolysis of adenosine triphosphate]]|abcg2 protein results in increased hydrolysis of adenosine triphosphate
|
https://ctdbase.org/detail.go?type=gene&acc=9429
|
||
|
ABCG2
|
Homo sapiens (human)
|
Luteolin affects the activity of ABCG2 protein
|
https://ctdbase.org/detail.go?type=gene&acc=9429
|
||
|
ABCG2
|
Homo sapiens (human)
|
Quercetin results in increased expression of ABCG2 mrna|quercetin results in increased expression of ABCG2 protein|ahr protein promotes the reaction [quercetin results in increased expression of ABCG2 protein]
|
https://ctdbase.org/detail.go?type=gene&acc=9429
|
||
|
ABCG2
|
Homo sapiens (human)
|
Quercetin affects the expression of ABCG2 mRNA
|
https://ctdbase.org/detail.go?type=gene&acc=9429
|
||
|
ABCG2
|
Homo sapiens (human)
|
Quercetin results in decreased expression of ABCG2 mrna|quercetin results in decreased expression of ABCG2 protein
|
https://ctdbase.org/detail.go?type=gene&acc=9429
|
||
|
ABCG2
|
Mus musculus (house mouse)
|
ABCG2 protein affects the export of quercetin metabolite|abcg2 protein affects the export of quercetin
|
https://ctdbase.org/detail.go?type=gene&acc=9429
|
||
|
ABCG2
|
Homo sapiens (human)
|
|
https://www.dgidb.org/genes/hgnc:74
|
||
|
ABCG2
|
Mus musculus (house mouse)
|
Probenecid inhibits the reaction [potassium oxonate results in increased expression of ABCG2 protein]
|
https://ctdbase.org/detail.go?type=gene&acc=9429
|
||
|
ABCG2
|
Homo sapiens (human)
|
Silymarin results in increased expression of ABCG2 protein|ahr protein promotes the reaction [silymarin results in increased expression of ABCG2 protein]
|
https://ctdbase.org/detail.go?type=gene&acc=9429
|
||
|
ABCG2
|
Homo sapiens (human)
|
Benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [indolo(3,2-b)carbazole results in increased expression of ABCG2 mrna]
|
https://ctdbase.org/detail.go?type=gene&acc=9429
|
||
|
ABCG2
|
Homo sapiens (human)
|
Hippuric acid inhibits the reaction [ABCG2 protein results in increased export of estrone sulfate]
|
https://ctdbase.org/detail.go?type=gene&acc=9429
|
||
|
ABCG2
|
Homo sapiens (human)
|
Colforsin inhibits the reaction [anandamide inhibits the reaction [CREB1 protein modified form binds to ABCG2 promoter]]
|
https://ctdbase.org/detail.go?type=gene&acc=9429
|
||
|
ABCG2
|
Homo sapiens (human)
|
Colforsin results in increased expression of ABCG2 mRNA
|
https://ctdbase.org/detail.go?type=gene&acc=9429
|
||
|
ABCG2
|
Mus musculus (house mouse)
|
ABCG2 protein affects the export of hymecromone analog
|
https://ctdbase.org/detail.go?type=gene&acc=9429
|
||
|
ABCG2
|
Homo sapiens (human)
|
Flavonoids results in decreased activity of ABCG2 protein
|
https://ctdbase.org/detail.go?type=gene&acc=9429
|
||
|
ABCG2
|
Homo sapiens (human)
|
[glycochenodeoxycholic acid co-treated with deoxycholic acid co-treated with chenodeoxycholic acid co-treated with glycodeoxycholic acid co-treated with glycocholic acid co-treated with 6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt] results in increased expression of ABCG2 mrna|[glycochenodeoxycholic acid co-treated with deoxycholic acid co-treated with chenodeoxycholic acid co-treated with glycodeoxycholic acid co-treated with glycocholic acid co-treated with atazanavir sulfate] results in increased expression of ABCG2 mrna|[glycochenodeoxycholic acid co-treated with deoxycholic acid co-treated with chenodeoxycholic acid co-treated with glycodeoxycholic acid co-treated with glycocholic acid co-treated with nefazodone] results in increased expression of ABCG2 mrna|[glycochenodeoxycholic acid co-treated with deoxycholic acid co-treated with chenodeoxycholic acid co-treated with glycodeoxycholic acid co-treated with glycocholic acid co-treated with tartrazine] results in decreased expression of ABCG2 mrna|[glycochenodeoxycholic acid co-treated with deoxycholic acid co-treated with chenodeoxycholic acid co-treated with glycodeoxycholic acid co-treated with glycocholic acid co-treated with cyclosporine] results in increased expression of ABCG2 mRNA
|
https://ctdbase.org/detail.go?type=gene&acc=9429
|
||
|
ABCG2
|
Homo sapiens (human)
|
[docetaxel results in decreased susceptibility to docetaxel] which results in decreased expression of ABCG2 mRNA
|
https://ctdbase.org/detail.go?type=gene&acc=9429
|
||
|
ABCG2
|
Homo sapiens (human)
|
|
https://www.dgidb.org/genes/hgnc:74
|
||
|
ABCG2
|
Oryctolagus cuniculus (rabbit)
|
Chlormequat inhibits the reaction [ABCG2 protein results in increased secretion of bisbenzimide ethoxide trihydrochloride]
|
https://ctdbase.org/detail.go?type=gene&acc=9429
|
||
|
ABCG2
|
Homo sapiens (human)
|
AHR protein promotes the reaction [2-tert-butylhydroquinone results in increased expression of ABCG2 protein]|2-tert-butylhydroquinone results in increased expression of ABCG2 mrna|2-tert-butylhydroquinone results in increased expression of ABCG2 protein
|
https://ctdbase.org/detail.go?type=gene&acc=9429
|
||
|
ABCG2
|
Mus musculus (house mouse)
|
Allopurinol inhibits the reaction [[oxonic acid analog co-treated with hypoxanthine] results in decreased expression of ABCG2 mrna]|allopurinol inhibits the reaction [[oxonic acid analog co-treated with hypoxanthine] results in decreased expression of ABCG2 protein]
|
https://ctdbase.org/detail.go?type=gene&acc=9429
|
||
|
ABCG2
|
Mus musculus (house mouse)
|
Allopurinol inhibits the reaction [potassium oxonate results in increased expression of ABCG2 protein]
|
https://ctdbase.org/detail.go?type=gene&acc=9429
|
||
|
ABCG2
|
Homo sapiens (human)
|
[3-(6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino(1',2'-1,6)pyrido(3,4-b)indol-3-yl)propionic acid tert-butyl ester results in decreased activity of ABCG2 protein] inhibits the reaction [folic acid deficiency results in decreased susceptibility to mitoxantrone]|[folic acid deficiency results in increased expression of ABCG2 protein] which results in decreased susceptibility to mitoxantrone|folic acid deficiency results in increased expression of ABCG2 protein|folic acid deficiency results in increased expression of ABCG2 mRNA
|
https://ctdbase.org/detail.go?type=gene&acc=9429
|
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