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Interactions between compounds and specific gene/protein targets.
| BIMP_ID | Target Name | Gene | Organism | Action | Source URL |
|---|---|---|---|---|---|
|
ABCG2
|
Rattus norvegicus (Norway rat)
|
Ethinyl estradiol results in decreased expression of ABCG2 mRNA
|
https://ctdbase.org/detail.go?type=gene&acc=9429
|
||
|
ABCG2
|
Rattus norvegicus (Norway rat)
|
Ethinyl estradiol results in decreased expression of and results in decreased activity of ABCG2 protein|fulvestrant inhibits the reaction [ethinyl estradiol results in decreased expression of ABCG2 protein]
|
https://ctdbase.org/detail.go?type=gene&acc=9429
|
||
|
ABCG2
|
Xenopus tropicalis (tropical clawed frog)
|
Ethinyl estradiol results in increased expression of ABCG2 mRNA
|
https://ctdbase.org/detail.go?type=gene&acc=9429
|
||
|
ABCG2
|
Homo sapiens (human)
|
ABCG2 affects the susceptibility to irinotecan
|
https://ctdbase.org/detail.go?type=gene&acc=9429
|
||
|
ABCG2
|
Homo sapiens (human)
|
ABCG2 protein affects the metabolism of irinotecan|abcg2 gene polymorphism affects the susceptibility to and affects the metabolism of irinotecan
|
https://ctdbase.org/detail.go?type=gene&acc=9429
|
||
|
ABCG2
|
Homo sapiens (human)
|
ABCG2 mRNA results in increased susceptibility to irinotecan
|
https://ctdbase.org/detail.go?type=gene&acc=9429
|
||
|
ABCG2
|
Homo sapiens (human)
|
ABCG2 protein affects the export of irinotecan
|
https://ctdbase.org/detail.go?type=gene&acc=9429
|
||
|
ABCG2
|
Homo sapiens (human)
|
ABCG2 protein results in decreased susceptibility to irinotecan
|
https://ctdbase.org/detail.go?type=gene&acc=9429
|
||
|
ABCG2
|
Homo sapiens (human)
|
ABCG2 protein results in increased susceptibility to irinotecan
|
https://ctdbase.org/detail.go?type=gene&acc=9429
|
||
|
ABCG2
|
Homo sapiens (human)
|
ABCG2 results in decreased susceptibility to irinotecan|reserpine inhibits the reaction [ABCG2 protein results in increased transport of irinotecan]|abcg2 protein results in increased transport of irinotecan
|
https://ctdbase.org/detail.go?type=gene&acc=9429
|
||
|
ABCG2
|
Homo sapiens (human)
|
Porphyrins inhibits the reaction [ABCG2 protein results in decreased susceptibility to irinotecan]
|
https://ctdbase.org/detail.go?type=gene&acc=9429
|
||
|
ABCG2
|
Mus musculus (house mouse)
|
ABCG2 protein affects the metabolism of irinotecan|bis(4-nitrophenyl)phosphate inhibits the reaction [ABCG2 protein affects the metabolism of irinotecan]|everolimus inhibits the reaction [ABCG2 protein affects the metabolism of irinotecan]
|
https://ctdbase.org/detail.go?type=gene&acc=9429
|
||
|
ABCG2
|
Homo sapiens (human)
|
ABCG2 protein results in increased export of irinotecan
|
https://ctdbase.org/detail.go?type=gene&acc=9429
|
||
|
ABCG2
|
Homo sapiens (human)
|
|
https://www.dgidb.org/genes/hgnc:74
|
||
|
ABCG2
|
Homo sapiens (human)
|
[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of ABCG2 mRNA
|
https://ctdbase.org/detail.go?type=gene&acc=9429
|
||
|
ABCG2
|
Mus musculus (house mouse)
|
Pirinixic acid results in increased expression of ABCG2 mRNA
|
https://ctdbase.org/detail.go?type=gene&acc=9429
|
||
|
ABCG2
|
Mus musculus (house mouse)
|
PPARA protein promotes the reaction [pirinixic acid results in increased expression of ABCG2 mrna]
|
https://ctdbase.org/detail.go?type=gene&acc=9429
|
||
|
ABCG2
|
Homo sapiens (human)
|
ABCG2 protein affects the reaction [mifepristone results in decreased transport of pheophorbide a]
|
https://ctdbase.org/detail.go?type=gene&acc=9429
|
||
|
ABCG2
|
Homo sapiens (human)
|
Triclosan results in increased expression of ABCG2 mRNA
|
https://ctdbase.org/detail.go?type=gene&acc=9429
|
||
|
ABCG2
|
Mus musculus (house mouse)
|
Tetracycline results in decreased expression of ABCG2 mRNA
|
https://ctdbase.org/detail.go?type=gene&acc=9429
|
||
|
ABCG2
|
Homo sapiens (human)
|
ABCG2 protein affects the transport of estrogens
|
https://ctdbase.org/detail.go?type=gene&acc=9429
|
||
|
ABCG2
|
Homo sapiens (human)
|
Estrone results in increased expression of ABCG2 mRNA
|
https://ctdbase.org/detail.go?type=gene&acc=9429
|
||
|
ABCG2
|
Homo sapiens (human)
|
Reserpine inhibits the reaction [ABCG2 protein results in increased transport of irinotecan]|reserpine inhibits the reaction [ABCG2 protein results in increased transport of bisbenzimide ethoxide trihydrochloride]
|
https://ctdbase.org/detail.go?type=gene&acc=9429
|
||
|
ABCG2
|
Homo sapiens (human)
|
|
https://www.dgidb.org/genes/hgnc:74
|
||
|
ABCG2
|
Rattus norvegicus (Norway rat)
|
[diethyl phthalate co-treated with diethylhexyl phthalate co-treated with dibutyl phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of ABCG2 mRNA
|
https://ctdbase.org/detail.go?type=gene&acc=9429
|
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