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Interactions between compounds and specific gene/protein targets.
| BIMP_ID | Target Name | Gene | Organism | Action | Source URL |
|---|---|---|---|---|---|
|
ABCB11
|
Homo sapiens (human)
|
[glycochenodeoxycholic acid co-treated with deoxycholic acid co-treated with chenodeoxycholic acid co-treated with glycodeoxycholic acid co-treated with glycocholic acid co-treated with 6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt] results in increased expression of ABCB11 mrna|[glycochenodeoxycholic acid co-treated with deoxycholic acid co-treated with chenodeoxycholic acid co-treated with glycodeoxycholic acid co-treated with glycocholic acid co-treated with acetaminophen] results in decreased expression of ABCB11 mrna|[glycochenodeoxycholic acid co-treated with deoxycholic acid co-treated with chenodeoxycholic acid co-treated with glycodeoxycholic acid co-treated with glycocholic acid co-treated with triclosan] results in increased expression of ABCB11 mRNA
|
https://ctdbase.org/detail.go?type=gene&acc=8647
|
||
|
ABCB11
|
Homo sapiens (human)
|
[glycochenodeoxycholic acid co-treated with deoxycholic acid co-treated with chenodeoxycholic acid co-treated with glycodeoxycholic acid co-treated with glycocholic acid] results in increased expression of ABCB11 mRNA
|
https://ctdbase.org/detail.go?type=gene&acc=8647
|
||
|
ABCB11
|
Mus musculus (house mouse)
|
SLCO1A1 protein affects the susceptibility to [deoxycholic acid results in decreased expression of ABCB11 mrna]|deoxycholic acid results in decreased expression of ABCB11 mRNA
|
https://ctdbase.org/detail.go?type=gene&acc=8647
|
||
|
ABCB11
|
Rattus norvegicus (Norway rat)
|
Deoxycholic acid results in increased expression of ABCB11 mRNA
|
https://ctdbase.org/detail.go?type=gene&acc=8647
|
||
|
ABCB11
|
Homo sapiens (human)
|
Atenolol results in decreased activity of ABCB11 protein|atenolol inhibits the reaction [ABCB11 protein results in increased transport of taurocholic acid]
|
https://ctdbase.org/detail.go?type=gene&acc=8647
|
||
|
ABCB11
|
Homo sapiens (human)
|
[catechin co-treated with grape seed proanthocyanidins] results in increased expression of ABCB11 mRNA
|
https://ctdbase.org/detail.go?type=gene&acc=8647
|
||
|
ABCB11
|
Homo sapiens (human)
|
Diethylhexyl phthalate results in decreased expression of ABCB11 mRNA
|
https://ctdbase.org/detail.go?type=gene&acc=8647
|
||
|
ABCB11
|
Mus musculus (house mouse)
|
Diethylhexyl phthalate results in decreased expression of ABCB11 mRNA
|
https://ctdbase.org/detail.go?type=gene&acc=8647
|
||
|
ABCB11
|
Mus musculus (house mouse)
|
[tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with diethylhexyl phthalate co-treated with bisphenol A] results in decreased expression of ABCB11 mRNA
|
https://ctdbase.org/detail.go?type=gene&acc=8647
|
||
|
ABCB11
|
Mus musculus (house mouse)
|
[furan co-treated with rhodioloside] results in increased expression of ABCB11 mRNA
|
https://ctdbase.org/detail.go?type=gene&acc=8647
|
||
|
ABCB11
|
Rattus norvegicus (Norway rat)
|
Furan results in decreased expression of ABCB11 mRNA
|
https://ctdbase.org/detail.go?type=gene&acc=8647
|
||
|
ABCB11
|
Mus musculus (house mouse)
|
[cephalothin co-treated with neomycin] results in increased expression of ABCB11 mRNA
|
https://ctdbase.org/detail.go?type=gene&acc=8647
|
||
|
ABCB11
|
Mus musculus (house mouse)
|
[vancomycin co-treated with neomycin co-treated with ampicillin co-treated with metronidazole co-treated with amphotericin B] results in increased expression of ABCB11 mRNA
|
https://ctdbase.org/detail.go?type=gene&acc=8647
|
||
|
ABCB11
|
Homo sapiens (human)
|
Clarithromycin results in decreased activity of ABCB11 protein|clarithromycin inhibits the reaction [ABCB11 protein results in increased transport of taurocholic acid]
|
https://ctdbase.org/detail.go?type=gene&acc=8647
|
||
|
ABCB11
|
Homo sapiens (human)
|
NADP promotes the reaction [[enzymes and coenzymes results in increased metabolism of saikogenin A] inhibits the reaction [ABCB11 protein results in increased transport of taurodeoxycholic acid]]|enzymes and coenzymes promotes the reaction [saikogenin A analog inhibits the reaction [ABCB11 protein results in increased transport of taurodeoxycholic acid]]|enzymes and coenzymes promotes the reaction [saikogenin A inhibits the reaction [ABCB11 protein results in increased transport of taurodeoxycholic acid]]|nadp promotes the reaction [[enzymes and coenzymes results in increased metabolism of saikogenin A analog] inhibits the reaction [ABCB11 protein results in increased transport of taurodeoxycholic acid]]|saikogenin A inhibits the reaction [ABCB11 protein results in increased transport of taurodeoxycholic acid]|[nadp co-treated with uridine diphosphate glucuronic acid co-treated with phosphoadenosine phosphosulfate] promotes the reaction [[enzymes and coenzymes results in increased metabolism of saikogenin A] inhibits the reaction [ABCB11 protein results in increased transport of taurodeoxycholic acid]]|[nadp co-treated with uridine diphosphate glucuronic acid co-treated with phosphoadenosine phosphosulfate] promotes the reaction [[enzymes and coenzymes results in increased metabolism of saikogenin A analog] inhibits the reaction [ABCB11 protein results in increased transport of taurodeoxycholic acid]]|saikogenin A analog inhibits the reaction [ABCB11 protein results in increased transport of taurodeoxycholic acid]
|
https://ctdbase.org/detail.go?type=gene&acc=8647
|
||
|
ABCB11
|
Mus musculus (house mouse)
|
Parathion results in decreased expression of ABCB11 mRNA
|
https://ctdbase.org/detail.go?type=gene&acc=8647
|
||
|
ABCB11
|
Homo sapiens (human)
|
[lithocholic acid binds to and results in increased activity of NR1H4 protein] which results in increased expression of ABCB11 mrna|[lithocholic acid analog binds to and results in increased activity of NR1H4 protein] which results in increased expression of ABCB11 mRNA
|
https://ctdbase.org/detail.go?type=gene&acc=8647
|
||
|
ABCB11
|
Homo sapiens (human)
|
Lithocholic acid results in increased expression of ABCB11 mRNA
|
https://ctdbase.org/detail.go?type=gene&acc=8647
|
||
|
ABCB11
|
Mus musculus (house mouse)
|
Lithocholic acid promotes the reaction [NR1H3 protein results in increased expression of ABCB11 mrna]
|
https://ctdbase.org/detail.go?type=gene&acc=8647
|
||
|
ABCB11
|
Mus musculus (house mouse)
|
Lithocholic acid results in decreased expression of ABCB11 mRNA
|
https://ctdbase.org/detail.go?type=gene&acc=8647
|
||
|
ABCB11
|
Mus musculus (house mouse)
|
Lithocholic acid results in increased expression of ABCB11 mRNA
|
https://ctdbase.org/detail.go?type=gene&acc=8647
|
||
|
ABCB11
|
Mus musculus (house mouse)
|
1,3-butadiene results in increased expression of ABCB11 mRNA
|
https://ctdbase.org/detail.go?type=gene&acc=8647
|
||
|
ABCB11
|
Mus musculus (house mouse)
|
1,3-butadiene results in decreased expression of ABCB11 mRNA
|
https://ctdbase.org/detail.go?type=gene&acc=8647
|
||
|
ABCB11
|
Homo sapiens (human)
|
Rosiglitazone inhibits the reaction [ABCB11 protein results in increased transport of taurocholic acid]
|
https://ctdbase.org/detail.go?type=gene&acc=8647
|
||
|
ABCB11
|
Homo sapiens (human)
|
Rosiglitazone results in decreased activity of ABCB11 protein
|
https://ctdbase.org/detail.go?type=gene&acc=8647
|
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