Molecular Targets : Dataset Browser

BIMP_ID	Target Name	Gene	Organism	Action	Source URL
BIMP082445	ABCB11	ABCB11	Mus musculus (house mouse)	NR1H4 promotes the reaction [yangonin promotes the reaction [1-naphthylisothiocyanate results in increased expression of ABCB11 protein]]\|yangonin results in increased expression of ABCB11 mrna\|yangonin promotes the reaction [1-naphthylisothiocyanate results in increased expression of ABCB11 mrna]\|pregna-4,17-diene-3,16-dione inhibits the reaction [yangonin promotes the reaction [1-naphthylisothiocyanate results in increased expression of ABCB11 mrna]]\|yangonin results in increased expression of ABCB11 protein\|yangonin promotes the reaction [1-naphthylisothiocyanate results in increased expression of ABCB11 protein]	https://ctdbase.org/detail.go?type=gene&acc=8647
BIMP082226	ABCB11	ABCB11	Homo sapiens (human)	Alpha-linolenic acid promotes the reaction [GW 4064 results in increased expression of ABCB11 mrna]	https://ctdbase.org/detail.go?type=gene&acc=8647
BIMP082224	ABCB11	ABCB11	Homo sapiens (human)	Senecionine results in decreased expression of ABCB11 mRNA	https://ctdbase.org/detail.go?type=gene&acc=8647
BIMP082224	ABCB11	ABCB11	Mus musculus (house mouse)	Senecionine results in decreased expression of ABCB11 mRNA	https://ctdbase.org/detail.go?type=gene&acc=8647
BIMP090555	ABCB11	ABCB11	Homo sapiens (human)	Reserpine inhibits the reaction [ABCB11 protein results in increased transport of taurocholic acid]	https://ctdbase.org/detail.go?type=gene&acc=8647
BIMP090555	ABCB11	ABCB11	Homo sapiens (human)	Reserpine results in decreased activity of ABCB11 protein	https://ctdbase.org/detail.go?type=gene&acc=8647
BIMP090682	ABCB11	ABCB11	Homo sapiens (human)	Spironolactone inhibits the reaction [ABCB11 protein results in increased transport of taurocholic acid]\|spironolactone results in decreased activity of ABCB11 protein	https://ctdbase.org/detail.go?type=gene&acc=8647
BIMP090994	ABCB11	ABCB11	Homo sapiens (human)	Adenosine triphosphate promotes the reaction [ABCB11 protein results in increased uptake of fexofenadine]	https://ctdbase.org/detail.go?type=gene&acc=8647
BIMP063786	ABCB11	ABCB11	Rattus norvegicus (Norway rat)	Acetamide results in decreased expression of ABCB11 mRNA	https://ctdbase.org/detail.go?type=gene&acc=8647
BIMP063594	ABCB11	ABCB11	Mus musculus (house mouse)	[ATP7B gene mutant form results in increased susceptibility to zinc acetate] which results in increased expression of ABCB11 mrna\|[atp7b gene mutant form results in increased susceptibility to zinc acetate] promotes the reaction [RXRA protein binds to ABCB11 promoter]\|[atp7b gene mutant form results in increased susceptibility to zinc acetate] promotes the reaction [NR1H4 protein binds to ABCB11 promoter]	https://ctdbase.org/detail.go?type=gene&acc=8647
BIMP063553	ABCB11	ABCB11	Homo sapiens (human)	[NADP co-treated with uridine diphosphate glucuronic acid co-treated with phosphoadenosine phosphosulfate] promotes the reaction [[enzymes and coenzymes results in increased metabolism of diosbulbin B] inhibits the reaction [ABCB11 protein results in increased transport of taurodeoxycholic acid]]\|[nadp co-treated with uridine diphosphate glucuronic acid co-treated with phosphoadenosine phosphosulfate] promotes the reaction [[enzymes and coenzymes results in increased metabolism of saikogenin A analog] inhibits the reaction [ABCB11 protein results in increased transport of taurodeoxycholic acid]]\|[nadp co-treated with uridine diphosphate glucuronic acid co-treated with phosphoadenosine phosphosulfate] promotes the reaction [[enzymes and coenzymes results in increased metabolism of saikogenin A] inhibits the reaction [ABCB11 protein results in increased transport of taurodeoxycholic acid]]	https://ctdbase.org/detail.go?type=gene&acc=8647
BIMP063574	ABCB11	ABCB11	Mus musculus (house mouse)	Acadesine inhibits the reaction [picroside II inhibits the reaction [1-naphthylisothiocyanate results in decreased expression of ABCB11 protein]]\|acadesine inhibits the reaction [picroside II inhibits the reaction [1-naphthylisothiocyanate results in decreased expression of ABCB11 mrna]]	https://ctdbase.org/detail.go?type=gene&acc=8647
BIMP064420	ABCB11	ABCB11	Gallus gallus (chicken)	Aflatoxin B1 results in increased expression of ABCB11 protein\|[aflatoxin B1 co-treated with selenium deficiency] results in increased expression of ABCB11 protein	https://ctdbase.org/detail.go?type=gene&acc=8647
BIMP064420	ABCB11	ABCB11	Homo sapiens (human)	Aflatoxin B1 results in decreased expression of ABCB11 mrna\|aflatoxin B1 results in increased expression of ABCB11 mRNA	https://ctdbase.org/detail.go?type=gene&acc=8647
BIMP064420	ABCB11	ABCB11	Homo sapiens (human)	Aflatoxin B1 results in decreased methylation of ABCB11 gene	https://ctdbase.org/detail.go?type=gene&acc=8647
BIMP064420	ABCB11	ABCB11	Mus musculus (house mouse)	Aflatoxin B1 results in decreased expression of ABCB11 mRNA	https://ctdbase.org/detail.go?type=gene&acc=8647
BIMP065145	ABCB11	ABCB11	Mus musculus (house mouse)	[mono-(2-ethylhexyl)phthalate co-treated with tretinoin] results in decreased expression of ABCB11 mRNA	https://ctdbase.org/detail.go?type=gene&acc=8647
BIMP065009	ABCB11	ABCB11	Homo sapiens (human)	Carboxyatractyloside inhibits the reaction [ABCB11 protein results in increased transport of taurodeoxycholic acid]	https://ctdbase.org/detail.go?type=gene&acc=8647
BIMP066307	ABCB11	ABCB11	Homo sapiens (human)	Saikogenin F inhibits the reaction [ABCB11 protein results in increased transport of taurodeoxycholic acid]	https://ctdbase.org/detail.go?type=gene&acc=8647
BIMP066605	ABCB11	ABCB11	Homo sapiens (human)	Sorafenib results in decreased activity of ABCB11 protein	https://ctdbase.org/detail.go?type=gene&acc=8647
BIMP016244	ABCB11	ABCB11	Homo sapiens (human)	Dihydrotanshinone I inhibits the reaction [ABCB11 protein results in increased transport of taurodeoxycholic acid]	https://ctdbase.org/detail.go?type=gene&acc=8647
BIMP005388	ABCB11	ABCB11	Homo sapiens (human)	Enzymes and coenzymes inhibits the reaction [rhein promotes the reaction [ABCB11 protein results in increased transport of taurodeoxycholic acid]]\|rhein metabolite inhibits the reaction [ABCB11 protein results in increased transport of taurodeoxycholic acid]\|rhein promotes the reaction [ABCB11 protein results in increased transport of taurodeoxycholic acid]	https://ctdbase.org/detail.go?type=gene&acc=8647
BIMP007957	ABCB11	ABCB11	Rattus norvegicus (Norway rat)	Chrysophanic acid results in decreased expression of ABCB11 mrna\|chrysophanic acid results in decreased expression of ABCB11 protein	https://ctdbase.org/detail.go?type=gene&acc=8647
BIMP008216	ABCB11	ABCB11	Homo sapiens (human)	[NADP co-treated with uridine diphosphate glucuronic acid co-treated with phosphoadenosine phosphosulfate] promotes the reaction [[enzymes and coenzymes results in increased metabolism of diosbulbin B] inhibits the reaction [ABCB11 protein results in increased transport of taurodeoxycholic acid]]\|[nadp co-treated with uridine diphosphate glucuronic acid co-treated with phosphoadenosine phosphosulfate] promotes the reaction [[enzymes and coenzymes results in increased metabolism of saikogenin A analog] inhibits the reaction [ABCB11 protein results in increased transport of taurodeoxycholic acid]]\|[nadp co-treated with uridine diphosphate glucuronic acid co-treated with phosphoadenosine phosphosulfate] promotes the reaction [[enzymes and coenzymes results in increased metabolism of saikogenin A] inhibits the reaction [ABCB11 protein results in increased transport of taurodeoxycholic acid]]	https://ctdbase.org/detail.go?type=gene&acc=8647
BIMP004027	ABCB11	ABCB11	Rattus norvegicus (Norway rat)	Boldine results in increased expression of ABCB11 mrna\|boldine results in increased expression of ABCB11 protein	https://ctdbase.org/detail.go?type=gene&acc=8647

BIMP082445

ABCB11

Mus musculus (house mouse)

NR1H4 promotes the reaction [yangonin promotes the reaction [1-naphthylisothiocyanate results in increased expression of ABCB11 protein]]|yangonin results in increased expression of ABCB11 mrna|yangonin promotes the reaction [1-naphthylisothiocyanate results in increased expression of ABCB11 mrna]|pregna-4,17-diene-3,16-dione inhibits the reaction [yangonin promotes the reaction [1-naphthylisothiocyanate results in increased expression of ABCB11 mrna]]|yangonin results in increased expression of ABCB11 protein|yangonin promotes the reaction [1-naphthylisothiocyanate results in increased expression of ABCB11 protein]