Molecular Targets : Dataset Browser

BIMP_ID	Target Name	Gene	Organism	Action	Source URL
BIMP072300	ABCB1	ABCB1	Homo sapiens (human)	Doxorubicin results in increased expression of ABCB1 protein	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP072300	ABCB1	ABCB1	Homo sapiens (human)	Flupenthixol analog inhibits the reaction [ABCB1 protein results in decreased susceptibility to doxorubicin]	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP072300	ABCB1	ABCB1	Homo sapiens (human)	Ketoconazole inhibits the reaction [doxorubicin results in increased expression of ABCB1 mrna]\|glutathione inhibits the reaction [doxorubicin results in increased expression of ABCB1 mrna]	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP072300	ABCB1	ABCB1	Homo sapiens (human)	Haloperidol inhibits the reaction [ABCB1 protein results in decreased susceptibility to doxorubicin]	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP072300	ABCB1	ABCB1	Homo sapiens (human)	[[[[hyaluronic acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of CTNNB1 protein] which results in increased expression of ABCB1 protein] inhibits the reaction [doxorubicin results in increased activity of CASP3 protein]\|[[[[hyaluronic acid binds to CD44 protein] which results in increased expression of and results in increased activity of EP300 protein] which results in increased acetylation of and results in increased activity of RELA protein] which results in increased expression of ABCB1 protein] inhibits the reaction [doxorubicin results in increased activity of CASP3 protein]	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP072300	ABCB1	ABCB1	Homo sapiens (human)	Meloxicam inhibits the reaction [doxorubicin results in increased expression of ABCB1 protein]\|meloxicam inhibits the reaction [doxorubicin results in increased activity of ABCB1 protein]	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP072300	ABCB1	ABCB1	Homo sapiens (human)	Metformin inhibits the reaction [doxorubicin results in increased expression of ABCB1 mrna]	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP072300	ABCB1	ABCB1	Homo sapiens (human)	N-cyano-1-((3,4-dimethoxyphenyl)methyl)-3,4-dihydro-6,7-dimethoxy-N'-octyl-2(1H)-isoquinoline-carboximidamide inhibits the reaction [ABCB1 protein results in decreased susceptibility to doxorubicin]	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP072300	ABCB1	ABCB1	Homo sapiens (human)	[paclitaxel results in increased expression of ABCB1] which results in decreased susceptibility to doxorubicin	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP072300	ABCB1	ABCB1	Homo sapiens (human)	Pluronic block copolymer p85 inhibits the reaction [doxorubicin results in increased expression of ABCB1 protein]	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP072300	ABCB1	ABCB1	Homo sapiens (human)	Psorospermin inhibits the reaction [ABCB1 protein results in decreased susceptibility to doxorubicin]	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP072300	ABCB1	ABCB1	Homo sapiens (human)	[quercetin co-treated with doxorubicin] results in decreased expression of ABCB1 protein	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP072300	ABCB1	ABCB1	Homo sapiens (human)	Quercetin inhibits the reaction [doxorubicin results in increased expression of ABCB1 mrna]	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP072300	ABCB1	ABCB1	Homo sapiens (human)	[RAB6C protein affects the expression of ABCB1 mrna] which affects the susceptibility to doxorubicin	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP072300	ABCB1	ABCB1	Homo sapiens (human)	Valspodar inhibits the reaction [[[tretinoin co-treated with romidepsin] results in increased expression of ABCB1 mrna] which results in decreased susceptibility to doxorubicin]\|[[tretinoin co-treated with romidepsin] results in increased expression of ABCB1 mrna] which results in decreased susceptibility to doxorubicin	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP072300	ABCB1	ABCB1	Homo sapiens (human)	Verapamil inhibits the reaction [ABCB1 protein results in decreased susceptibility to doxorubicin]	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP072300	ABCB1	ABCB1	Homo sapiens (human)	Verapamil inhibits the reaction [ABCB1 protein results in decreased uptake of doxorubicin]	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP072300	ABCB1	ABCB1	Homo sapiens (human)	Verapamil inhibits the reaction [ABCB1 protein results in increased export of doxorubicin]	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP072300	ABCB1	ABCB1	Mus musculus (house mouse)	[doxorubicin co-treated with polyisohexylcyanoacrylate] results in increased expression of ABCB1 mRNA	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP072300	ABCB1	ABCB1	Mus musculus (house mouse)	Doxorubicin results in increased expression of ABCB1 mRNA	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP072300	ABCB1	ABCB1	Mus musculus (house mouse)	Zinc chloride inhibits the reaction [doxorubicin results in increased expression of ABCB1 mrna]	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP072300	ABCB1	ABCB1	Rattus norvegicus (Norway rat)	ABCB1 protein results in decreased susceptibility to doxorubicin	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP072300	ABCB1	ABCB1	Homo sapiens (human)	Crizotinib inhibits the reaction [ABCB1 protein results in decreased susceptibility to doxorubicin]	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP072300	ABCB1	ABCB1	Homo sapiens (human)	ABCB1 promoter modified form results in decreased susceptibility to doxorubicin	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP072300	ABCB1	ABCB1	Homo sapiens (human)	Loperamide inhibits the reaction [doxorubicin results in increased expression of ABCB1 mrna]	https://ctdbase.org/detail.go?type=gene&acc=5243

BIMP072300

ABCB1

Homo sapiens (human)

Doxorubicin results in increased expression of ABCB1 protein