Molecular Targets : Dataset Browser

BIMP_ID	Target Name	Gene	Organism	Action	Source URL
BIMP072300	ABCB1	ABCB1	Homo sapiens (human)	ABCB1 protein results in decreased uptake of doxorubicin	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP072300	ABCB1	ABCB1	Homo sapiens (human)	Lapatinib inhibits the reaction [ABCB1 protein results in increased export of and results in decreased susceptibility to doxorubicin]\|abcb1 protein results in increased export of and results in decreased susceptibility to doxorubicin\|tryptoquivaline inhibits the reaction [ABCB1 protein results in increased export of doxorubicin]	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP072300	ABCB1	ABCB1	Homo sapiens (human)	ABCB1 protein results in increased export of doxorubicin	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP072300	ABCB1	ABCB1	Homo sapiens (human)	ABCB1 protein results in increased transport of and affects the susceptibility to doxorubicin	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP072300	ABCB1	ABCB1	Homo sapiens (human)	Verapamil inhibits the reaction [ABCB1 protein results in increased transport of doxorubicin]\|[carvedilol inhibits the reaction [ABCB1 protein results in increased transport of doxorubicin]] which results in decreased susceptibility to doxorubicin\|carvedilol inhibits the reaction [ABCB1 protein results in increased transport of doxorubicin]\|abcb1 protein results in increased transport of doxorubicin	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP072300	ABCB1	ABCB1	Homo sapiens (human)	ABCB1 protein results in increased uptake of doxorubicin	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP072300	ABCB1	ABCB1	Homo sapiens (human)	ABCB1 results in decreased susceptibility to doxorubicin	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP072300	ABCB1	ABCB1	Homo sapiens (human)	Abemaciclib inhibits the reaction [ABCB1 protein results in increased export of doxorubicin]	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP072300	ABCB1	ABCB1	Homo sapiens (human)	Verapamil inhibits the reaction [doxorubicin results in increased activity of ABCB1 protein]\|acetaminophen promotes the reaction [ABCB1 protein results in decreased uptake of doxorubicin]	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP072300	ABCB1	ABCB1	Homo sapiens (human)	Gambogic acid affects the reaction [ABCB1 protein affects the susceptibility to doxorubicin]\|acetylcysteine affects the reaction [[gambogic acid affects the reaction [ABCB1 protein affects the susceptibility to doxorubicin]] which affects the cleavage of PARP1 protein]\|[gambogic acid affects the reaction [ABCB1 protein affects the susceptibility to doxorubicin]] which affects the cleavage of CASP7 protein\|acetylcysteine affects the reaction [[gambogic acid affects the reaction [ABCB1 protein affects the susceptibility to doxorubicin]] which affects the cleavage of CASP7 protein]\|[gambogic acid affects the reaction [ABCB1 protein affects the susceptibility to doxorubicin]] which affects the cleavage of PARP1 protein	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP072300	ABCB1	ABCB1	Homo sapiens (human)	Mometasone furoate inhibits the reaction [ABCB1 protein results in decreased susceptibility to doxorubicin]\|beclomethasone inhibits the reaction [ABCB1 protein results in decreased susceptibility to doxorubicin]\|desisobutyrylciclesonide inhibits the reaction [ABCB1 protein results in decreased susceptibility to doxorubicin]	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP072300	ABCB1	ABCB1	Homo sapiens (human)	Betulin inhibits the reaction [ABCB1 protein results in decreased susceptibility to doxorubicin]\|doxorubicin inhibits the reaction [ABCB1 protein results in increased export of doxorubicin]	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP072300	ABCB1	ABCB1	Homo sapiens (human)	[bortezomib co-treated with doxorubicin] results in decreased expression of ABCB1 protein\|[pentoxifylline co-treated with doxorubicin] results in decreased expression of ABCB1 protein	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP072300	ABCB1	ABCB1	Homo sapiens (human)	[carvedilol results in decreased activity of ABCB1 protein] which results in increased susceptibility to doxorubicin\|[verapamil results in decreased activity of ABCB1 protein] which results in increased susceptibility to doxorubicin	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP072300	ABCB1	ABCB1	Homo sapiens (human)	CEP 33779 inhibits the reaction [ABCB1 protein results in decreased susceptibility to doxorubicin]\|cep 33779 inhibits the reaction [ABCB1 protein results in increased export of doxorubicin]	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP072300	ABCB1	ABCB1	Homo sapiens (human)	Chlorpyrifos inhibits the reaction [ABCB1 protein results in increased export of doxorubicin]\|endosulfan inhibits the reaction [ABCB1 protein results in increased export of doxorubicin]\|clotrimazole inhibits the reaction [ABCB1 protein results in increased export of doxorubicin]\|hydramethylnon inhibits the reaction [ABCB1 protein results in increased export of doxorubicin]\|ivermectin inhibits the reaction [ABCB1 protein results in increased export of doxorubicin]\|parathion inhibits the reaction [ABCB1 protein results in increased export of doxorubicin]	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP072300	ABCB1	ABCB1	Homo sapiens (human)	Cycloserine inhibits the reaction [ABCB1 protein results in decreased susceptibility to doxorubicin]\|fumonisin B1 inhibits the reaction [ABCB1 protein results in decreased susceptibility to doxorubicin]	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP072300	ABCB1	ABCB1	Homo sapiens (human)	Cyclosporine inhibits the reaction [ABCB1 protein results in decreased susceptibility to doxorubicin]	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP072300	ABCB1	ABCB1	Homo sapiens (human)	Valspodar inhibits the reaction [ABCB1 protein results in decreased uptake of doxorubicin]\|valspodar inhibits the reaction [ABCB1 protein results in decreased susceptibility to doxorubicin]\|cyclosporine inhibits the reaction [ABCB1 protein results in decreased uptake of doxorubicin]	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP072300	ABCB1	ABCB1	Homo sapiens (human)	[ouabain results in increased expression of ABCB1] which results in decreased susceptibility to doxorubicin\|[digoxin results in increased expression of ABCB1] which results in decreased susceptibility to doxorubicin	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP072300	ABCB1	ABCB1	Homo sapiens (human)	HIF1A protein affects the reaction [[doxorubicin co-treated with IL6 protein] results in increased expression of ABCB1 protein]\|[doxorubicin co-treated with IL6 protein] results in increased expression of ABCB1 protein	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP072300	ABCB1	ABCB1	Homo sapiens (human)	Doxorubicin results in decreased expression of ABCB1 protein	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP072300	ABCB1	ABCB1	Homo sapiens (human)	Doxorubicin results in increased activity of ABCB1 protein	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP072300	ABCB1	ABCB1	Homo sapiens (human)	Doxorubicin results in increased expression of ABCB1	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP072300	ABCB1	ABCB1	Homo sapiens (human)	Doxorubicin results in increased expression of ABCB1 mRNA	https://ctdbase.org/detail.go?type=gene&acc=5243

BIMP072300

ABCB1

Homo sapiens (human)

ABCB1 protein results in decreased uptake of doxorubicin