Molecular Targets : Dataset Browser

BIMP_ID	Target Name	Gene	Organism	Action	Source URL
BIMP071166	ABCB1	ABCB1	Homo sapiens (human)	[citronellal results in decreased activity of ABCB1 protein] which results in decreased export of digoxin\|[citronellol results in decreased activity of ABCB1 protein] which results in decreased export of digoxin\|[plant extracts results in decreased activity of ABCB1 protein] which results in decreased export of digoxin	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP071166	ABCB1	ABCB1	Homo sapiens (human)	Curcumin inhibits the reaction [ABCB1 protein results in increased transport of digoxin]\|gingerol inhibits the reaction [ABCB1 protein results in increased transport of digoxin]	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP071166	ABCB1	ABCB1	Homo sapiens (human)	Cyazofamid affects the reaction [ABCB1 protein results in increased uptake of digoxin]	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP071166	ABCB1	ABCB1	Homo sapiens (human)	[verapamil binds to and results in decreased activity of ABCB1 protein] which results in decreased export of digoxin\|digoxin binds to ABCB1 protein\|[cyclosporine binds to and results in decreased activity of ABCB1 protein] which results in decreased export of digoxin\|[ketoconazole binds to and results in decreased activity of ABCB1 protein] which results in decreased export of digoxin\|[elacridar binds to and results in decreased activity of ABCB1 protein] which results in decreased export of digoxin	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP071166	ABCB1	ABCB1	Homo sapiens (human)	Diazinon affects the reaction [ABCB1 protein results in increased transport of digoxin]	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP071166	ABCB1	ABCB1	Homo sapiens (human)	Digoxin inhibits the reaction [ABCB1 protein results in increased transport of quinidinium]\|abcb1 protein affects the metabolism of digoxin	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP071166	ABCB1	ABCB1	Homo sapiens (human)	[ketoconazole results in decreased activity of ABCB1 protein] which results in increased uptake of digoxin\|[isopropyl 5,12-hydroxypentadeca-8,10-dien-6,14-diynoate results in decreased activity of ABCB1 protein] which results in increased uptake of digoxin\|[elacridar results in decreased activity of ABCB1 protein] which results in increased uptake of digoxin	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP071166	ABCB1	ABCB1	Homo sapiens (human)	Fusidic acid inhibits the reaction [ABCB1 protein results in increased export of digoxin]	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP071166	ABCB1	ABCB1	Homo sapiens (human)	Itraconazole inhibits the reaction [ABCB1 protein affects the transport of digoxin]\|ketoconazole inhibits the reaction [ABCB1 protein affects the transport of digoxin]	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP071166	ABCB1	ABCB1	Homo sapiens (human)	Spinosad inhibits the reaction [ABCB1 protein results in increased transport of digoxin]	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP071166	ABCB1	ABCB1	Homo sapiens (human)	Valspodar inhibits the reaction [ABCB1 protein results in increased transport of digoxin]	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP071166	ABCB1	ABCB1	Homo sapiens (human)	[verapamil results in decreased activity of ABCB1 protein] which results in decreased transport of digoxin\|[valspodar results in decreased activity of ABCB1 protein] which results in decreased transport of digoxin	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP071166	ABCB1	ABCB1	Homo sapiens (human)	Verapamil inhibits the reaction [ABCB1 protein results in increased transport of digoxin]	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP071166	ABCB1	ABCB1	Ovis aries (sheep)	Cyclosporine inhibits the reaction [ABCB1 results in decreased uptake of digoxin]\|abcb1 results in decreased uptake of digoxin\|verapamil inhibits the reaction [ABCB1 results in decreased uptake of digoxin]	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP071166	ABCB1	ABCB1	Rattus norvegicus (Norway rat)	ABCB1 protein affects the secretion of digoxin	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP071166	ABCB1	ABCB1	Rattus norvegicus (Norway rat)	Acetaminophen promotes the reaction [ABCB1 protein results in increased transport of digoxin]\|abcb1 protein results in increased transport of digoxin	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP071166	ABCB1	ABCB1	Rattus norvegicus (Norway rat)	[P-glycoprotein inducer and activator TX5 results in increased activity of ABCB1 protein] which results in increased export of digoxin	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP071185	ABCB1	ABCB1	Homo sapiens (human)	Fumonisin B1 inhibits the reaction [ABCB1 protein results in decreased susceptibility to doxorubicin]	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP071185	ABCB1	ABCB1	Rattus norvegicus (Norway rat)	Fumonisin B1 inhibits the reaction [nickel chloride results in increased expression of ABCB1 protein]	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP071186	ABCB1	ABCB1	Homo sapiens (human)		https://www.dgidb.org/genes/hgnc:40
BIMP071241	ABCB1	ABCB1	Cricetulus griseus (Chinese hamster)	Sesquiterpenes analog inhibits the reaction [ABCB1 protein affects the transport of tetramethylrosamine]	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP071241	ABCB1	ABCB1	Cricetulus griseus (Chinese hamster)	Tetramethylrosamine inhibits the reaction [ABCB1 protein results in increased transport of cypermethrin]\|tetramethylrosamine inhibits the reaction [ABCB1 protein results in increased transport of endosulfan]\|tetramethylrosamine inhibits the reaction [ABCB1 protein results in increased transport of methyl parathion]\|tetramethylrosamine inhibits the reaction [ABCB1 protein results in increased transport of fenvalerate]	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP071304	ABCB1	ABCB1	Cyprinus carpio (common carp)	Clotrimazole results in decreased expression of ABCB1 mRNA	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP071304	ABCB1	ABCB1	Homo sapiens (human)	Clotrimazole binds to ABCB1 protein\|clotrimazole inhibits the reaction [ABCB1 protein results in increased export of doxorubicin]	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP071304	ABCB1	ABCB1	Homo sapiens (human)	Clotrimazole inhibits the reaction [ABCB1 protein results in increased secretion of fluorexon]\|clotrimazole inhibits the reaction [ABCB1 protein results in increased secretion of vinblastine]	https://ctdbase.org/detail.go?type=gene&acc=5243

BIMP071166

ABCB1

Homo sapiens (human)

[citronellal results in decreased activity of ABCB1 protein] which results in decreased export of digoxin|[citronellol results in decreased activity of ABCB1 protein] which results in decreased export of digoxin|[plant extracts results in decreased activity of ABCB1 protein] which results in decreased export of digoxin

https://ctdbase.org/detail.go?type=gene&acc=5243

BIMP071166

ABCB1

Homo sapiens (human)

Curcumin inhibits the reaction [ABCB1 protein results in increased transport of digoxin]|gingerol inhibits the reaction [ABCB1 protein results in increased transport of digoxin]

https://ctdbase.org/detail.go?type=gene&acc=5243

BIMP071166

ABCB1

Homo sapiens (human)

Cyazofamid affects the reaction [ABCB1 protein results in increased uptake of digoxin]

https://ctdbase.org/detail.go?type=gene&acc=5243

BIMP071166

ABCB1

Homo sapiens (human)

[verapamil binds to and results in decreased activity of ABCB1 protein] which results in decreased export of digoxin|digoxin binds to ABCB1 protein|[cyclosporine binds to and results in decreased activity of ABCB1 protein] which results in decreased export of digoxin|[ketoconazole binds to and results in decreased activity of ABCB1 protein] which results in decreased export of digoxin|[elacridar binds to and results in decreased activity of ABCB1 protein] which results in decreased export of digoxin

https://ctdbase.org/detail.go?type=gene&acc=5243

BIMP071166

ABCB1

Homo sapiens (human)

Diazinon affects the reaction [ABCB1 protein results in increased transport of digoxin]

https://ctdbase.org/detail.go?type=gene&acc=5243

BIMP071166

ABCB1

Homo sapiens (human)

Digoxin inhibits the reaction [ABCB1 protein results in increased transport of quinidinium]|abcb1 protein affects the metabolism of digoxin

https://ctdbase.org/detail.go?type=gene&acc=5243

BIMP071166

ABCB1

Homo sapiens (human)

[ketoconazole results in decreased activity of ABCB1 protein] which results in increased uptake of digoxin|[isopropyl 5,12-hydroxypentadeca-8,10-dien-6,14-diynoate results in decreased activity of ABCB1 protein] which results in increased uptake of digoxin|[elacridar results in decreased activity of ABCB1 protein] which results in increased uptake of digoxin

https://ctdbase.org/detail.go?type=gene&acc=5243

BIMP071166

ABCB1

Homo sapiens (human)

Fusidic acid inhibits the reaction [ABCB1 protein results in increased export of digoxin]

https://ctdbase.org/detail.go?type=gene&acc=5243

BIMP071166

ABCB1

Homo sapiens (human)

Itraconazole inhibits the reaction [ABCB1 protein affects the transport of digoxin]|ketoconazole inhibits the reaction [ABCB1 protein affects the transport of digoxin]

https://ctdbase.org/detail.go?type=gene&acc=5243

BIMP071166

ABCB1

Homo sapiens (human)

Spinosad inhibits the reaction [ABCB1 protein results in increased transport of digoxin]

https://ctdbase.org/detail.go?type=gene&acc=5243

BIMP071166

ABCB1

Homo sapiens (human)

Valspodar inhibits the reaction [ABCB1 protein results in increased transport of digoxin]

https://ctdbase.org/detail.go?type=gene&acc=5243

BIMP071166

ABCB1

Homo sapiens (human)

[verapamil results in decreased activity of ABCB1 protein] which results in decreased transport of digoxin|[valspodar results in decreased activity of ABCB1 protein] which results in decreased transport of digoxin

https://ctdbase.org/detail.go?type=gene&acc=5243

BIMP071166

ABCB1

Homo sapiens (human)

Verapamil inhibits the reaction [ABCB1 protein results in increased transport of digoxin]

https://ctdbase.org/detail.go?type=gene&acc=5243

BIMP071166

ABCB1

Ovis aries (sheep)

Cyclosporine inhibits the reaction [ABCB1 results in decreased uptake of digoxin]|abcb1 results in decreased uptake of digoxin|verapamil inhibits the reaction [ABCB1 results in decreased uptake of digoxin]

https://ctdbase.org/detail.go?type=gene&acc=5243

BIMP071166

ABCB1

Rattus norvegicus (Norway rat)

ABCB1 protein affects the secretion of digoxin

https://ctdbase.org/detail.go?type=gene&acc=5243

BIMP071166

ABCB1

Rattus norvegicus (Norway rat)

Acetaminophen promotes the reaction [ABCB1 protein results in increased transport of digoxin]|abcb1 protein results in increased transport of digoxin

https://ctdbase.org/detail.go?type=gene&acc=5243

BIMP071166

ABCB1

Rattus norvegicus (Norway rat)

[P-glycoprotein inducer and activator TX5 results in increased activity of ABCB1 protein] which results in increased export of digoxin

https://ctdbase.org/detail.go?type=gene&acc=5243

BIMP071185

ABCB1

Homo sapiens (human)

Fumonisin B1 inhibits the reaction [ABCB1 protein results in decreased susceptibility to doxorubicin]

https://ctdbase.org/detail.go?type=gene&acc=5243

BIMP071185

ABCB1

Rattus norvegicus (Norway rat)

Fumonisin B1 inhibits the reaction [nickel chloride results in increased expression of ABCB1 protein]

https://ctdbase.org/detail.go?type=gene&acc=5243

BIMP071186

ABCB1

Homo sapiens (human)

https://www.dgidb.org/genes/hgnc:40

BIMP071241

ABCB1

Cricetulus griseus (Chinese hamster)

Sesquiterpenes analog inhibits the reaction [ABCB1 protein affects the transport of tetramethylrosamine]

https://ctdbase.org/detail.go?type=gene&acc=5243

BIMP071241

ABCB1

Cricetulus griseus (Chinese hamster)

Tetramethylrosamine inhibits the reaction [ABCB1 protein results in increased transport of cypermethrin]|tetramethylrosamine inhibits the reaction [ABCB1 protein results in increased transport of endosulfan]|tetramethylrosamine inhibits the reaction [ABCB1 protein results in increased transport of methyl parathion]|tetramethylrosamine inhibits the reaction [ABCB1 protein results in increased transport of fenvalerate]

https://ctdbase.org/detail.go?type=gene&acc=5243

BIMP071304

ABCB1

Cyprinus carpio (common carp)

Clotrimazole results in decreased expression of ABCB1 mRNA

https://ctdbase.org/detail.go?type=gene&acc=5243

BIMP071304

ABCB1

Homo sapiens (human)

Clotrimazole binds to ABCB1 protein|clotrimazole inhibits the reaction [ABCB1 protein results in increased export of doxorubicin]

https://ctdbase.org/detail.go?type=gene&acc=5243

BIMP071304

ABCB1

Homo sapiens (human)

Clotrimazole inhibits the reaction [ABCB1 protein results in increased secretion of fluorexon]|clotrimazole inhibits the reaction [ABCB1 protein results in increased secretion of vinblastine]

https://ctdbase.org/detail.go?type=gene&acc=5243