SCFBio, IIT Delhi
Hauz Khas, New Delhi
BIMP
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SCFBio, IIT Delhi
Interactions between compounds and specific gene/protein targets.
| BIMP_ID | Target Name | Gene | Organism | Action | Source URL |
|---|---|---|---|---|---|
|
ABCB1
|
Rattus norvegicus (Norway rat)
|
[methionine deficiency co-treated with choline deficiency] results in increased expression of ABCB1 protein|[methionine deficiency co-treated with choline deficiency] results in increased expression of ABCB1 mRNA
|
https://ctdbase.org/detail.go?type=gene&acc=5243
|
||
|
ABCB1
|
Homo sapiens (human)
|
Ketoconazole inhibits the reaction [3,3'-diindolylmethane results in increased expression of ABCB1 mrna]|3,3'-diindolylmethane results in increased expression of ABCB1 mrna|[3,3'-diindolylmethane results in increased activity of NR1I2 protein] which results in increased expression of ABCB1 mRNA
|
https://ctdbase.org/detail.go?type=gene&acc=5243
|
||
|
ABCB1
|
Rattus norvegicus (Norway rat)
|
Diphenyleneiodonium inhibits the reaction [vehicle emissions results in increased expression of and results in increased activity of ABCB1 protein]|diphenyleneiodonium inhibits the reaction [particulate matter results in increased expression of and results in increased activity of ABCB1 protein]
|
https://ctdbase.org/detail.go?type=gene&acc=5243
|
||
|
ABCB1
|
Homo sapiens (human)
|
|
https://www.dgidb.org/genes/hgnc:40
|
||
|
ABCB1
|
Bos taurus (cattle)
|
[TNF protein results in increased expression of ABCB1 protein] which results in increased export of digoxin
|
https://ctdbase.org/detail.go?type=gene&acc=5243
|
||
|
ABCB1
|
Canis lupus familiaris (dog)
|
ABCB1 gene mutant form affects the reaction [digoxin affects the expression of EBF3 mrna]|abcb1 gene mutant form affects the reaction [digoxin affects the expression of GABRQ mrna]|abcb1 gene mutant form affects the reaction [digoxin affects the expression of TTR mrna]|abcb1 gene mutant form affects the reaction [digoxin affects the expression of GLRA1 mrna]|abcb1 gene mutant form affects the reaction [digoxin affects the expression of ALB mrna]|abcb1 gene mutant form affects the reaction [digoxin affects the expression of DAO mrna]|abcb1 gene mutant form affects the reaction [digoxin affects the expression of MAB21L2 mrna]|abcb1 gene mutant form results in increased susceptibility to digoxin|abcb1 gene mutant form affects the reaction [digoxin affects the expression of KLK6 mrna]|abcb1 gene mutant form affects the reaction [digoxin affects the expression of SLC18A2 mrna]|abcb1 gene mutant form affects the reaction [digoxin affects the expression of SLC10A4 mrna]
|
https://ctdbase.org/detail.go?type=gene&acc=5243
|
||
|
ABCB1
|
Canis lupus familiaris (dog)
|
ABCB1 mutant form results in increased susceptibility to digoxin
|
https://ctdbase.org/detail.go?type=gene&acc=5243
|
||
|
ABCB1
|
Canis lupus familiaris (dog)
|
[ML 7 results in decreased activity of MYLK protein] affects the reaction [ABCB1 protein affects the transport of digoxin]|[verapamil results in decreased activity of ABCB1 protein] which affects the transport of digoxin|myl9 protein modified form affects the reaction [ABCB1 protein affects the transport of digoxin analog]
|
https://ctdbase.org/detail.go?type=gene&acc=5243
|
||
|
ABCB1
|
Homo sapiens (human)
|
Rhodioloside affects the reaction [ABCB1 protein results in increased transport of digoxin]|18alpha-glycyrrhetinic acid inhibits the reaction [ABCB1 protein results in increased transport of digoxin]|emodin inhibits the reaction [ABCB1 protein results in increased transport of digoxin]|ginsenoside F2 analog inhibits the reaction [ABCB1 protein results in increased transport of digoxin]|dehydroandrographolide inhibits the reaction [ABCB1 protein results in increased transport of digoxin]
|
https://ctdbase.org/detail.go?type=gene&acc=5243
|
||
|
ABCB1
|
Homo sapiens (human)
|
KN 93 inhibits the reaction [digoxin results in increased expression of ABCB1 protein]|2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [digoxin results in increased expression of ABCB1 protein]|3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction [digoxin results in increased expression of ABCB1 mrna]|digoxin results in increased expression of ABCB1 protein|3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole inhibits the reaction [digoxin results in increased expression of ABCB1 protein]|[digoxin results in increased expression of ABCB1] which results in decreased susceptibility to doxorubicin|digoxin results in increased expression of ABCB1 mRNA
|
https://ctdbase.org/detail.go?type=gene&acc=5243
|
||
|
ABCB1
|
Homo sapiens (human)
|
Sinensetin inhibits the reaction [ABCB1 protein results in increased transport of digoxin]|5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [ABCB1 protein results in increased transport of digoxin]|tangeretin inhibits the reaction [ABCB1 protein results in increased transport of digoxin]|sinensetin analog inhibits the reaction [ABCB1 protein results in increased transport of digoxin]|nobiletin inhibits the reaction [ABCB1 protein results in increased transport of digoxin]|sciadopitysin inhibits the reaction [ABCB1 protein results in increased transport of digoxin]
|
https://ctdbase.org/detail.go?type=gene&acc=5243
|
||
|
ABCB1
|
Homo sapiens (human)
|
ABCB1 gene SNP affects the abundance of digoxin
|
https://ctdbase.org/detail.go?type=gene&acc=5243
|
||
|
ABCB1
|
Homo sapiens (human)
|
Ketoconazole inhibits the reaction [ABCB1 protein results in increased transport of digoxin]|abcb1 gene SNP affects the transport of digoxin|rifampin promotes the reaction [ABCB1 protein results in increased transport of digoxin]
|
https://ctdbase.org/detail.go?type=gene&acc=5243
|
||
|
ABCB1
|
Homo sapiens (human)
|
ABCB1 protein affects the transport of digoxin
|
https://ctdbase.org/detail.go?type=gene&acc=5243
|
||
|
ABCB1
|
Homo sapiens (human)
|
ABCB1 protein binds to and affects the metabolism of digoxin
|
https://ctdbase.org/detail.go?type=gene&acc=5243
|
||
|
ABCB1
|
Homo sapiens (human)
|
ABCB1 protein results in decreased uptake of digoxin
|
https://ctdbase.org/detail.go?type=gene&acc=5243
|
||
|
ABCB1
|
Homo sapiens (human)
|
ABCB1 protein results in increased export of digoxin
|
https://ctdbase.org/detail.go?type=gene&acc=5243
|
||
|
ABCB1
|
Homo sapiens (human)
|
ABCB1 protein results in increased transport of digoxin
|
https://ctdbase.org/detail.go?type=gene&acc=5243
|
||
|
ABCB1
|
Homo sapiens (human)
|
ABCB1 protein results in increased uptake of digoxin|verapamil inhibits the reaction [ABCB1 protein results in increased uptake of digoxin]
|
https://ctdbase.org/detail.go?type=gene&acc=5243
|
||
|
ABCB1
|
Homo sapiens (human)
|
Citronellal inhibits the reaction [ABCB1 protein results in increased uptake of digoxin]|ophiobolin A inhibits the reaction [ABCB1 protein results in increased uptake of digoxin]|glycyrrhetinic acid inhibits the reaction [ABCB1 protein results in increased uptake of digoxin]|terpinolene inhibits the reaction [ABCB1 protein results in increased uptake of digoxin]|abietic acid inhibits the reaction [ABCB1 protein results in increased uptake of digoxin]|beta-pinene inhibits the reaction [ABCB1 protein results in increased uptake of digoxin]|cucurbitacin I inhibits the reaction [ABCB1 protein results in increased uptake of digoxin]|gamma-terpinene inhibits the reaction [ABCB1 protein results in increased uptake of digoxin]|citronellol inhibits the reaction [ABCB1 protein results in increased uptake of digoxin]
|
https://ctdbase.org/detail.go?type=gene&acc=5243
|
||
|
ABCB1
|
Homo sapiens (human)
|
Desmethylazelastine inhibits the reaction [ABCB1 protein results in increased transport of digoxin]|desethylamiodarone inhibits the reaction [ABCB1 protein results in increased transport of digoxin]|azelastine inhibits the reaction [ABCB1 protein results in increased transport of digoxin]|amiodarone inhibits the reaction [ABCB1 protein results in increased transport of digoxin]
|
https://ctdbase.org/detail.go?type=gene&acc=5243
|
||
|
ABCB1
|
Homo sapiens (human)
|
Bepridil inhibits the reaction [ABCB1 protein results in increased transport of digoxin]|manidipine inhibits the reaction [ABCB1 protein results in increased transport of digoxin]|nilvadipine inhibits the reaction [ABCB1 protein results in increased transport of digoxin]|nisoldipine inhibits the reaction [ABCB1 protein results in increased transport of digoxin]|benidipine inhibits the reaction [ABCB1 protein results in increased transport of digoxin]|efonidipine inhibits the reaction [ABCB1 protein results in increased transport of digoxin]|mepirodipine inhibits the reaction [ABCB1 protein results in increased transport of digoxin]|diltiazem inhibits the reaction [ABCB1 protein results in increased transport of digoxin]|nicardipine inhibits the reaction [ABCB1 protein results in increased transport of digoxin]|doxazosin inhibits the reaction [ABCB1 protein results in increased transport of digoxin]
|
https://ctdbase.org/detail.go?type=gene&acc=5243
|
||
|
ABCB1
|
Homo sapiens (human)
|
Bisoprolol inhibits the reaction [ABCB1 protein results in increased transport of digoxin]|propranolol inhibits the reaction [ABCB1 protein results in increased transport of digoxin]
|
https://ctdbase.org/detail.go?type=gene&acc=5243
|
||
|
ABCB1
|
Homo sapiens (human)
|
Capsaicin affects the reaction [ABCB1 protein results in increased export of digoxin]
|
https://ctdbase.org/detail.go?type=gene&acc=5243
|
||
|
ABCB1
|
Homo sapiens (human)
|
Carvedilol inhibits the reaction [ABCB1 protein results in increased transport of digoxin]
|
https://ctdbase.org/detail.go?type=gene&acc=5243
|
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