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Interactions between compounds and specific gene/protein targets.
| BIMP_ID | Target Name | Gene | Organism | Action | Source URL |
|---|---|---|---|---|---|
|
ABCB1
|
Homo sapiens (human)
|
Valproic acid affects the expression of ABCB1 mRNA
|
https://ctdbase.org/detail.go?type=gene&acc=5243
|
||
|
ABCB1
|
Homo sapiens (human)
|
Valproic acid results in decreased activity of ABCB1 protein
|
https://ctdbase.org/detail.go?type=gene&acc=5243
|
||
|
ABCB1
|
Homo sapiens (human)
|
Valproic acid results in decreased methylation of ABCB1 gene
|
https://ctdbase.org/detail.go?type=gene&acc=5243
|
||
|
ABCB1
|
Homo sapiens (human)
|
Valproic acid results in increased expression of ABCB1 mRNA
|
https://ctdbase.org/detail.go?type=gene&acc=5243
|
||
|
ABCB1
|
Rattus norvegicus (Norway rat)
|
Valproic acid results in increased expression of ABCB1 protein
|
https://ctdbase.org/detail.go?type=gene&acc=5243
|
||
|
ABCB1
|
Homo sapiens (human)
|
|
https://www.dgidb.org/genes/hgnc:40
|
||
|
ABCB1
|
Homo sapiens (human)
|
NR1I2 protein promotes the reaction [notoginsenoside R1 results in increased expression of ABCB1 mrna]|notoginsenoside R1 results in increased expression of ABCB1 mRNA
|
https://ctdbase.org/detail.go?type=gene&acc=5243
|
||
|
ABCB1
|
Homo sapiens (human)
|
|
https://www.dgidb.org/genes/hgnc:40
|
||
|
ABCB1
|
Homo sapiens (human)
|
ABCB1 protein results in increased transport of digitoxin
|
https://ctdbase.org/detail.go?type=gene&acc=5243
|
||
|
ABCB1
|
Homo sapiens (human)
|
Digitoxin inhibits the reaction [ABCB1 protein results in increased transport of quinidinium]
|
https://ctdbase.org/detail.go?type=gene&acc=5243
|
||
|
ABCB1
|
Homo sapiens (human)
|
|
https://www.dgidb.org/genes/hgnc:40
|
||
|
ABCB1
|
Homo sapiens (human)
|
Hyperforin inhibits the reaction [ABCB1 protein results in increased secretion of ritonavir]
|
https://ctdbase.org/detail.go?type=gene&acc=5243
|
||
|
ABCB1
|
Homo sapiens (human)
|
Hyperforin results in increased expression of ABCB1
|
https://ctdbase.org/detail.go?type=gene&acc=5243
|
||
|
ABCB1
|
Homo sapiens (human)
|
Hyperforin results in increased expression of ABCB1 mRNA
|
https://ctdbase.org/detail.go?type=gene&acc=5243
|
||
|
ABCB1
|
Canis lupus familiaris (dog)
|
[verapamil results in decreased activity of ABCB1 protein] which results in decreased transport of hypaconitine|abcb1 protein results in increased transport of hypaconitine|[cyclosporine results in decreased activity of ABCB1 protein] which results in decreased transport of hypaconitine
|
https://ctdbase.org/detail.go?type=gene&acc=5243
|
||
|
ABCB1
|
Homo sapiens (human)
|
Cymarine inhibits the reaction [ABCB1 protein results in increased transport of quinidinium]
|
https://ctdbase.org/detail.go?type=gene&acc=5243
|
||
|
ABCB1
|
Bos taurus (cattle)
|
Quinidine results in decreased activity of ABCB1 protein
|
https://ctdbase.org/detail.go?type=gene&acc=5243
|
||
|
ABCB1
|
Heliothis virescens (tobacco budworm)
|
Quinidine inhibits the reaction [ABCB1 protein results in decreased susceptibility to thiodicarb]|quinidine results in decreased activity of ABCB1 protein
|
https://ctdbase.org/detail.go?type=gene&acc=5243
|
||
|
ABCB1
|
Heliothis virescens (tobacco budworm)
|
Quinidine inhibits the reaction [ABCB1 protein results in increased export of and results in decreased susceptibility to thiodicarb]
|
https://ctdbase.org/detail.go?type=gene&acc=5243
|
||
|
ABCB1
|
Homo sapiens (human)
|
ABCB1 protein affects the transport of quinidine
|
https://ctdbase.org/detail.go?type=gene&acc=5243
|
||
|
ABCB1
|
Homo sapiens (human)
|
ABCB1 protein results in increased transport of quinidine
|
https://ctdbase.org/detail.go?type=gene&acc=5243
|
||
|
ABCB1
|
Homo sapiens (human)
|
Methoxyfenozide inhibits the reaction [ABCB1 protein results in increased transport of quinidine]|tebufenozide inhibits the reaction [ABCB1 protein results in increased transport of quinidine]
|
https://ctdbase.org/detail.go?type=gene&acc=5243
|
||
|
ABCB1
|
Homo sapiens (human)
|
Quinidine binds to ABCB1 protein
|
https://ctdbase.org/detail.go?type=gene&acc=5243
|
||
|
ABCB1
|
Homo sapiens (human)
|
Quinidine inhibits the reaction [ABCB1 protein results in decreased susceptibility to paclitaxel]|quinidine inhibits the reaction [ABCB1 protein results in decreased susceptibility to docetaxel]|quinidine results in decreased expression of ABCB1 protein
|
https://ctdbase.org/detail.go?type=gene&acc=5243
|
||
|
ABCB1
|
Homo sapiens (human)
|
Quinidine binds to ABCB1 protein
|
https://ctdbase.org/detail.go?type=gene&acc=5243
|
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