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Interactions between compounds and specific gene/protein targets.
| BIMP_ID | Target Name | Gene | Organism | Action | Source URL |
|---|---|---|---|---|---|
|
ABCB1
|
Homo sapiens (human)
|
Baicalein results in increased expression of ABCB1 mRNA
|
https://ctdbase.org/detail.go?type=gene&acc=5243
|
||
|
ABCB1
|
Homo sapiens (human)
|
Galangin results in increased activity of ABCB1 protein|galangin inhibits the reaction [elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of daunorubicin]]|verapamil promotes the reaction [galangin results in increased activity of ABCB1 protein]|galangin results in increased expression of ABCB1 protein
|
https://ctdbase.org/detail.go?type=gene&acc=5243
|
||
|
ABCB1
|
Homo sapiens (human)
|
Galangin results in increased expression of ABCB1 mRNA
|
https://ctdbase.org/detail.go?type=gene&acc=5243
|
||
|
ABCB1
|
Rattus norvegicus (Norway rat)
|
Zearalenone results in increased expression of ABCB1 mRNA
|
https://ctdbase.org/detail.go?type=gene&acc=5243
|
||
|
ABCB1
|
Homo sapiens (human)
|
Cucurbitacin I inhibits the reaction [ABCB1 protein results in increased uptake of digoxin]
|
https://ctdbase.org/detail.go?type=gene&acc=5243
|
||
|
ABCB1
|
Homo sapiens (human)
|
Ophiobolin A inhibits the reaction [ABCB1 protein results in increased uptake of digoxin]
|
https://ctdbase.org/detail.go?type=gene&acc=5243
|
||
|
ABCB1
|
Homo sapiens (human)
|
Chrysin affects the activity of ABCB1 protein
|
https://ctdbase.org/detail.go?type=gene&acc=5243
|
||
|
ABCB1
|
Homo sapiens (human)
|
Chrysin results in decreased activity of ABCB1 protein|chrysin results in increased expression of ABCB1 protein|[chrysin results in decreased activity of ABCB1 protein] which results in decreased export of topotecan
|
https://ctdbase.org/detail.go?type=gene&acc=5243
|
||
|
ABCB1
|
Mus musculus (house mouse)
|
Chrysin results in decreased activity of ABCB1 protein
|
https://ctdbase.org/detail.go?type=gene&acc=5243
|
||
|
ABCB1
|
Homo sapiens (human)
|
Daidzein inhibits the reaction [elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of rhodamine 123]]
|
https://ctdbase.org/detail.go?type=gene&acc=5243
|
||
|
ABCB1
|
Homo sapiens (human)
|
Myricetin results in increased activity of ABCB1 protein|myricetin inhibits the reaction [ABCB1 protein results in decreased uptake of rhodamine 123]|myricetin results in increased expression of ABCB1 protein
|
https://ctdbase.org/detail.go?type=gene&acc=5243
|
||
|
ABCB1
|
Homo sapiens (human)
|
Sciadopitysin results in decreased activity of ABCB1 protein|sciadopitysin inhibits the reaction [ABCB1 protein results in increased transport of digoxin]
|
https://ctdbase.org/detail.go?type=gene&acc=5243
|
||
|
ABCB1
|
Homo sapiens (human)
|
Tamarixetin results in increased expression of ABCB1 mRNA
|
https://ctdbase.org/detail.go?type=gene&acc=5243
|
||
|
ABCB1
|
Homo sapiens (human)
|
Mangiferin results in increased expression of ABCB1 protein|dichlororibofuranosylbenzimidazole inhibits the reaction [mangiferin results in increased expression of ABCB1 protein]|mangiferin results in increased expression of ABCB1 mRNA
|
https://ctdbase.org/detail.go?type=gene&acc=5243
|
||
|
ABCB1
|
Homo sapiens (human)
|
3-methylquercetin results in increased activity of ABCB1 protein|3-methylquercetin inhibits the reaction [ABCB1 protein results in decreased uptake of rhodamine 123]|3-methylquercetin results in decreased expression of ABCB1 protein|3-methylquercetin promotes the reaction [elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of rhodamine 123]]|3-methylquercetin promotes the reaction [quercetin results in increased activity of ABCB1 protein]
|
https://ctdbase.org/detail.go?type=gene&acc=5243
|
||
|
ABCB1
|
Homo sapiens (human)
|
3-methylquercetin results in increased expression of ABCB1 mRNA
|
https://ctdbase.org/detail.go?type=gene&acc=5243
|
||
|
ABCB1
|
Homo sapiens (human)
|
ABCB1 protein results in increased transport of 3-methylquercetin
|
https://ctdbase.org/detail.go?type=gene&acc=5243
|
||
|
ABCB1
|
Homo sapiens (human)
|
Norathyriol results in increased expression of ABCB1 protein
|
https://ctdbase.org/detail.go?type=gene&acc=5243
|
||
|
ABCB1
|
Homo sapiens (human)
|
Kaempferide inhibits the reaction [elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of daunorubicin]]|kaempferide inhibits the reaction [ABCB1 protein results in decreased uptake of daunorubicin]
|
https://ctdbase.org/detail.go?type=gene&acc=5243
|
||
|
ABCB1
|
Mus musculus (house mouse)
|
Kuwanon G results in increased expression of ABCB1 protein|kuwanon G results in increased expression of ABCB1 mrna|geranylgeranyl pyrophosphate inhibits the reaction [kuwanon G results in increased expression of ABCB1 protein]
|
https://ctdbase.org/detail.go?type=gene&acc=5243
|
||
|
ABCB1
|
Homo sapiens (human)
|
Morin promotes the reaction [quercetin results in increased activity of ABCB1 protein]|morin results in increased activity of ABCB1 protein
|
https://ctdbase.org/detail.go?type=gene&acc=5243
|
||
|
ABCB1
|
Homo sapiens (human)
|
ABCB1 protein results in increased transport of proscillaridin
|
https://ctdbase.org/detail.go?type=gene&acc=5243
|
||
|
ABCB1
|
Homo sapiens (human)
|
Proscillaridin inhibits the reaction [ABCB1 protein results in increased transport of quinidinium]
|
https://ctdbase.org/detail.go?type=gene&acc=5243
|
||
|
ABCB1
|
Homo sapiens (human)
|
Ascorbic acid inhibits the reaction [3',4',7-trihydroxyisoflavone results in decreased expression of ABCB1 mrna]|cat protein inhibits the reaction [3',4',7-trihydroxyisoflavone results in decreased expression of ABCB1 mrna]|acetylcysteine inhibits the reaction [3',4',7-trihydroxyisoflavone results in decreased expression of ABCB1 mrna]|3',4',7-trihydroxyisoflavone inhibits the reaction [epirubicin results in increased expression of ABCB1 mrna]|3',4',7-trihydroxyisoflavone results in decreased expression of ABCB1 mRNA
|
https://ctdbase.org/detail.go?type=gene&acc=5243
|
||
|
ABCB1
|
Homo sapiens (human)
|
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [ABCB1 protein results in increased transport of digoxin]|5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased activity of ABCB1 protein
|
https://ctdbase.org/detail.go?type=gene&acc=5243
|
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