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SCFBio, IIT Delhi Hauz Khas, New Delhi

Molecular Targets

Interactions between compounds and specific gene/protein targets.

Total Rows 750,454
Pages 30,019
BIMP_ID Target Name Gene Organism Action Source URL
Bacillus cereus
https://www.drugbank.ca/bio_entities/BE0001955
plcA
Listeria monocytogenes EGD-e
https://www.drugbank.ca/bio_entities/BE0002943
Oryzias latipes (Japanese medaka)
Nonylphenol results in increased expression of 1-SF mRNA
https://ctdbase.org/detail.go?type=gene&acc=100049428
Platichthys flesus (European flounder)
Tert-butylhydroperoxide results in increased expression of 1-SF mRNA
https://ctdbase.org/detail.go?type=gene&acc=100049428
Oryzias latipes (Japanese medaka)
Bisphenol A results in increased expression of 1-SF mRNA
https://ctdbase.org/detail.go?type=gene&acc=100049428
Oryzias melastigma (Indian medaka)
Bisphenol A results in increased expression of 1-SF mRNA
https://ctdbase.org/detail.go?type=gene&acc=100049428
Oryzias melastigma (Indian medaka)
3,3'-diindolylmethane results in decreased expression of 1-SF mrna|3,3'-diindolylmethane affects the expression of 1-SF protein
https://ctdbase.org/detail.go?type=gene&acc=100049428
Oryzias latipes (Japanese medaka)
Estradiol results in increased expression of 1-SF mRNA
https://ctdbase.org/detail.go?type=gene&acc=100049428
Oryzias latipes (Japanese medaka)
Ethinyl estradiol results in increased expression of 1-SF mRNA
https://ctdbase.org/detail.go?type=gene&acc=100049428
Oryzias melastigma (Indian medaka)
Ethinyl estradiol results in increased expression of 1-SF mRNA
https://ctdbase.org/detail.go?type=gene&acc=100049428
Oryzias melastigma (Indian medaka)
4-nonylphenol results in increased expression of 1-SF mRNA
https://ctdbase.org/detail.go?type=gene&acc=100049428
HSPE1
Homo sapiens (human)
https://www.drugbank.ca/bio_entities/BE0009028
RDH5
Homo sapiens (human)
https://www.drugbank.ca/bio_entities/BE0000570
RDH5
Homo sapiens (human)
Substrate
https://www.drugbank.ca/bio_entities/BE0000570
RDH5
Homo sapiens (human)
Vision:vitamin A (all-<i>trans</i> retinol) is converted in the retina to the 11-<i>cis</i>-isomer of retinaldehyde or 11-<i>cis</i>-retinal. 11-<i>cis</i>-retinal functions in the retina in the transduction of light into the neural signals necessary for vision. 11-<i>cis</i>-retinal, while attached to opsin in rhodopsin is isomerized to all-<i>trans</i>-retinal by light. this is the event that triggers the nerve impulse to the brain which allows for the perception of light. all-<i>trans</i>-retinal is then released from opsin and reduced to all-<i>trans</i>-retinol. all-<i>trans</i>-retinol is isomerized to 11-<i>cis</i>-retinol in the dark, and then oxidized to 11-<i>cis</i>-retinal. 11-<i>cis</i>-retinal recombines with opsin to re-form rhodopsin. night blindness or defective vision at low illumination results from a failure to re-synthesize 11-<i>cis</i> retinal rapidly. <br/>epithelial differentiation: the role of vitamin A in epithelial differentiation, as well as in other physiological processes, involves the binding of vitamin A to two families of nuclear retinoid receptors (retinoic acid receptors, rars; and retinoid-X receptors, rxrs). these receptors function as ligand-activated transcription factors that modulate gene transcription. when there is not enough vitamin A to bind these receptors, natural cell differentiation and growth are interrupted.
http://www.t3db.ca/biodb/bio_entities/BE0000570
128up
Moina macrocopa
Methoprene results in decreased expression of 128UP mRNA
https://ctdbase.org/detail.go?type=gene&acc=36288
Smp_095360.1
Schistosoma mansoni
https://www.drugbank.ca/bio_entities/BE0001566
YWHAB
Homo sapiens (human)
https://www.drugbank.ca/bio_entities/BE0008974
YWHAE
Homo sapiens (human)
https://www.drugbank.ca/bio_entities/BE0004570
YWHAH
Homo sapiens (human)
https://www.drugbank.ca/bio_entities/BE0009041
YWHAQ
Homo sapiens (human)
https://www.drugbank.ca/bio_entities/BE0009042
YWHAZ
Homo sapiens (human)
https://www.drugbank.ca/bio_entities/BE0001174
14-3-3epsilon
Moina macrocopa
Methoprene results in increased expression of 14-3-3EPSILON mRNA
https://ctdbase.org/detail.go?type=gene&acc=42186
14-3-3zeta
Moina macrocopa
Methoprene results in decreased expression of 14-3-3ZETA mRNA
https://ctdbase.org/detail.go?type=gene&acc=36059
HPGD
Homo sapiens (human)
Substrate
https://www.drugbank.ca/bio_entities/BE0000552
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