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Interactions between compounds and specific gene/protein targets.
| BIMP_ID | Target Name | Gene | Organism | Action | Source URL |
|---|---|---|---|---|---|
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Bacillus cereus
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https://www.drugbank.ca/bio_entities/BE0001955
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plcA
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Listeria monocytogenes EGD-e
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https://www.drugbank.ca/bio_entities/BE0002943
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Oryzias latipes (Japanese medaka)
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Nonylphenol results in increased expression of 1-SF mRNA
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https://ctdbase.org/detail.go?type=gene&acc=100049428
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Platichthys flesus (European flounder)
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Tert-butylhydroperoxide results in increased expression of 1-SF mRNA
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https://ctdbase.org/detail.go?type=gene&acc=100049428
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Oryzias latipes (Japanese medaka)
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Bisphenol A results in increased expression of 1-SF mRNA
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https://ctdbase.org/detail.go?type=gene&acc=100049428
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Oryzias melastigma (Indian medaka)
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Bisphenol A results in increased expression of 1-SF mRNA
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https://ctdbase.org/detail.go?type=gene&acc=100049428
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Oryzias melastigma (Indian medaka)
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3,3'-diindolylmethane results in decreased expression of 1-SF mrna|3,3'-diindolylmethane affects the expression of 1-SF protein
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https://ctdbase.org/detail.go?type=gene&acc=100049428
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Oryzias latipes (Japanese medaka)
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Estradiol results in increased expression of 1-SF mRNA
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https://ctdbase.org/detail.go?type=gene&acc=100049428
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Oryzias latipes (Japanese medaka)
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Ethinyl estradiol results in increased expression of 1-SF mRNA
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https://ctdbase.org/detail.go?type=gene&acc=100049428
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Oryzias melastigma (Indian medaka)
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Ethinyl estradiol results in increased expression of 1-SF mRNA
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https://ctdbase.org/detail.go?type=gene&acc=100049428
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Oryzias melastigma (Indian medaka)
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4-nonylphenol results in increased expression of 1-SF mRNA
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https://ctdbase.org/detail.go?type=gene&acc=100049428
|
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HSPE1
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Homo sapiens (human)
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https://www.drugbank.ca/bio_entities/BE0009028
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RDH5
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Homo sapiens (human)
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https://www.drugbank.ca/bio_entities/BE0000570
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RDH5
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Homo sapiens (human)
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Substrate
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https://www.drugbank.ca/bio_entities/BE0000570
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RDH5
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Homo sapiens (human)
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Vision:vitamin A (all-<i>trans</i> retinol) is converted in the retina to the 11-<i>cis</i>-isomer of retinaldehyde or 11-<i>cis</i>-retinal. 11-<i>cis</i>-retinal functions in the retina in the transduction of light into the neural signals necessary for vision. 11-<i>cis</i>-retinal, while attached to opsin in rhodopsin is isomerized to all-<i>trans</i>-retinal by light. this is the event that triggers the nerve impulse to the brain which allows for the perception of light. all-<i>trans</i>-retinal is then released from opsin and reduced to all-<i>trans</i>-retinol. all-<i>trans</i>-retinol is isomerized to 11-<i>cis</i>-retinol in the dark, and then oxidized to 11-<i>cis</i>-retinal. 11-<i>cis</i>-retinal recombines with opsin to re-form rhodopsin. night blindness or defective vision at low illumination results from a failure to re-synthesize 11-<i>cis</i> retinal rapidly. <br/>epithelial differentiation: the role of vitamin A in epithelial differentiation, as well as in other physiological processes, involves the binding of vitamin A to two families of nuclear retinoid receptors (retinoic acid receptors, rars; and retinoid-X receptors, rxrs). these receptors function as ligand-activated transcription factors that modulate gene transcription. when there is not enough vitamin A to bind these receptors, natural cell differentiation and growth are interrupted.
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http://www.t3db.ca/biodb/bio_entities/BE0000570
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128up
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Moina macrocopa
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Methoprene results in decreased expression of 128UP mRNA
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https://ctdbase.org/detail.go?type=gene&acc=36288
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Smp_095360.1
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Schistosoma mansoni
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https://www.drugbank.ca/bio_entities/BE0001566
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YWHAB
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Homo sapiens (human)
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https://www.drugbank.ca/bio_entities/BE0008974
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YWHAE
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Homo sapiens (human)
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https://www.drugbank.ca/bio_entities/BE0004570
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YWHAH
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Homo sapiens (human)
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https://www.drugbank.ca/bio_entities/BE0009041
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YWHAQ
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Homo sapiens (human)
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https://www.drugbank.ca/bio_entities/BE0009042
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YWHAZ
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Homo sapiens (human)
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https://www.drugbank.ca/bio_entities/BE0001174
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14-3-3epsilon
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Moina macrocopa
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Methoprene results in increased expression of 14-3-3EPSILON mRNA
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https://ctdbase.org/detail.go?type=gene&acc=42186
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14-3-3zeta
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Moina macrocopa
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Methoprene results in decreased expression of 14-3-3ZETA mRNA
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https://ctdbase.org/detail.go?type=gene&acc=36059
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HPGD
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Homo sapiens (human)
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Substrate
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https://www.drugbank.ca/bio_entities/BE0000552
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No matching records found on this page.