SCFBio, IIT Delhi
Hauz Khas, New Delhi
BIMP
BIMP
Interactions
Organism
Gene Name
| S.No | BIMP ID | Organism | Action | References |
|---|---|---|---|---|
| 1 | BIMP074318 | Homo sapiens (human) | - | |
| 2 | BIMP077156 | Homo sapiens (human) | Vision:vitamin A (all-<i>trans</i> retinol) is converted in the retina to the 11-<i>cis</i>-isomer of retinaldehyde or 11-<i>cis</i>-retinal. 11-<i>cis</i>-retinal functions in the retina in the transduction of light into the neural signals necessary for vision. 11-<i>cis</i>-retinal, while attached to opsin in rhodopsin is isomerized to all-<i>trans</i>-retinal by light. this is the event that triggers the nerve impulse to the brain which allows for the perception of light. all-<i>trans</i>-retinal is then released from opsin and reduced to all-<i>trans</i>-retinol. all-<i>trans</i>-retinol is isomerized to 11-<i>cis</i>-retinol in the dark, and then oxidized to 11-<i>cis</i>-retinal. 11-<i>cis</i>-retinal recombines with opsin to re-form rhodopsin. night blindness or defective vision at low illumination results from a failure to re-synthesize 11-<i>cis</i> retinal rapidly. <br/>epithelial differentiation: the role of vitamin A in epithelial differentiation, as well as in other physiological processes, involves the binding of vitamin A to two families of nuclear retinoid receptors (retinoic acid receptors, rars; and retinoid-X receptors, rxrs). these receptors function as ligand-activated transcription factors that modulate gene transcription. when there is not enough vitamin A to bind these receptors, natural cell differentiation and growth are interrupted. | |
| 3 | BIMP077156 | Homo sapiens (human) | Substrate |