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Interactions between compounds and specific gene/protein targets.
| BIMP_ID | Target Name | Gene | Organism | Action | Source URL |
|---|---|---|---|---|---|
|
ABCC2
|
Danio rerio (zebrafish)
|
Ethinyl estradiol affects the expression of ABCC2 mRNA
|
https://ctdbase.org/detail.go?type=gene&acc=1244
|
||
|
ABCC2
|
Homo sapiens (human)
|
ABCC2 protein results in increased uptake of ethinyl estradiol metabolite|ethinyl estradiol metabolite promotes the reaction [ABCC2 protein results in increased uptake of estradiol-17 beta-glucuronide]
|
https://ctdbase.org/detail.go?type=gene&acc=1244
|
||
|
ABCC2
|
Homo sapiens (human)
|
Ethinyl estradiol results in decreased expression of ABCC2 mrna|prkaca protein affects the reaction [ethinyl estradiol results in decreased expression of ABCC2 mrna]|n-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [ursodeoxycholic acid inhibits the reaction [ethinyl estradiol results in decreased expression of ABCC2 mrna]]|prkacb protein affects the reaction [ethinyl estradiol results in decreased expression of ABCC2 mrna]|ursodeoxycholic acid inhibits the reaction [ethinyl estradiol results in decreased expression of ABCC2 mrna]|chenodeoxycholic acid inhibits the reaction [ethinyl estradiol results in decreased expression of ABCC2 mrna]|n-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [chenodeoxycholic acid inhibits the reaction [ethinyl estradiol results in decreased expression of ABCC2 mrna]]|8-bromo cyclic adenosine monophosphate inhibits the reaction [ethinyl estradiol results in decreased expression of ABCC2 mrna]
|
https://ctdbase.org/detail.go?type=gene&acc=1244
|
||
|
ABCC2
|
Homo sapiens (human)
|
Ethinyl estradiol results in increased expression of and results in increased activity of ABCC2 protein|fulvestrant inhibits the reaction [ethinyl estradiol results in increased expression of ABCC2 protein]
|
https://ctdbase.org/detail.go?type=gene&acc=1244
|
||
|
ABCC2
|
Mus musculus (house mouse)
|
Alisol B 23-acetate inhibits the reaction [ethinyl estradiol results in decreased expression of ABCC2 mrna]|pregna-4,17-diene-3,16-dione inhibits the reaction [alisol B 23-acetate inhibits the reaction [ethinyl estradiol results in decreased expression of ABCC2 mrna]]|alisol B 23-acetate inhibits the reaction [ethinyl estradiol results in decreased expression of ABCC2 protein]|pregna-4,17-diene-3,16-dione promotes the reaction [ethinyl estradiol results in decreased expression of ABCC2 mrna]
|
https://ctdbase.org/detail.go?type=gene&acc=1244
|
||
|
ABCC2
|
Mus musculus (house mouse)
|
Ethinyl estradiol results in decreased expression of ABCC2 mrna|ethinyl estradiol results in decreased expression of ABCC2 protein
|
https://ctdbase.org/detail.go?type=gene&acc=1244
|
||
|
ABCC2
|
Mus musculus (house mouse)
|
SRT1720 inhibits the reaction [ethinyl estradiol results in decreased expression of ABCC2 mrna]|srt1720 inhibits the reaction [ethinyl estradiol results in decreased expression of ABCC2 protein]
|
https://ctdbase.org/detail.go?type=gene&acc=1244
|
||
|
ABCC2
|
Rattus norvegicus (Norway rat)
|
GW 4064 inhibits the reaction [ethinyl estradiol results in decreased expression of ABCC2 protein]|dorsomorphin inhibits the reaction [ethinyl estradiol results in decreased expression of ABCC2 protein]|dorsomorphin inhibits the reaction [ethinyl estradiol results in decreased expression of ABCC2 mrna]|prkaa1 protein inhibits the reaction [ethinyl estradiol results in decreased expression of ABCC2 mrna]|nr1h4 protein inhibits the reaction [ethinyl estradiol results in decreased expression of ABCC2 mrna]
|
https://ctdbase.org/detail.go?type=gene&acc=1244
|
||
|
ABCC2
|
Rattus norvegicus (Norway rat)
|
Ethinyl estradiol affects the localization of ABCC2 protein
|
https://ctdbase.org/detail.go?type=gene&acc=1244
|
||
|
ABCC2
|
Rattus norvegicus (Norway rat)
|
[ethinyl estradiol co-treated with diosgenin] results in increased expression of ABCC2 mRNA
|
https://ctdbase.org/detail.go?type=gene&acc=1244
|
||
|
ABCC2
|
Rattus norvegicus (Norway rat)
|
[ethinyl estradiol co-treated with spironolactone] results in increased expression of ABCC2 protein
|
https://ctdbase.org/detail.go?type=gene&acc=1244
|
||
|
ABCC2
|
Rattus norvegicus (Norway rat)
|
Ethinyl estradiol results in decreased expression of ABCC2 mRNA
|
https://ctdbase.org/detail.go?type=gene&acc=1244
|
||
|
ABCC2
|
Rattus norvegicus (Norway rat)
|
Ethinyl estradiol results in decreased expression of ABCC2 protein
|
https://ctdbase.org/detail.go?type=gene&acc=1244
|
||
|
ABCC2
|
Rattus norvegicus (Norway rat)
|
Ethinyl estradiol results in decreased expression of and results in decreased localization of and results in decreased activity of ABCC2 protein|ursodeoxycholic acid inhibits the reaction [ethinyl estradiol results in decreased activity of ABCC2 protein]
|
https://ctdbase.org/detail.go?type=gene&acc=1244
|
||
|
ABCC2
|
Mus musculus (house mouse)
|
[ABCC1 gene mutant form results in increased susceptibility to testosterone deficiency] which results in increased expression of ABCC2 mrna|testosterone deficiency results in increased expression of ABCC2 mrna|abcc1 gene mutant form inhibits the reaction [testosterone deficiency results in increased expression of ABCC2 mrna]
|
https://ctdbase.org/detail.go?type=gene&acc=1244
|
||
|
ABCC2
|
Rattus norvegicus (Norway rat)
|
Testosterone inhibits the reaction [dexamethasone results in increased expression of ABCC2 mrna]
|
https://ctdbase.org/detail.go?type=gene&acc=1244
|
||
|
ABCC2
|
Homo sapiens (human)
|
ABCC2 protein results in decreased susceptibility to dinitrochlorobenzene
|
https://ctdbase.org/detail.go?type=gene&acc=1244
|
||
|
ABCC2
|
Homo sapiens (human)
|
|
https://www.dgidb.org/genes/hgnc:53
|
||
|
ABCC2
|
Homo sapiens (human)
|
ABCC2 protein results in increased uptake of phlorhizin|verlukast promotes the reaction [ABCC2 protein results in increased uptake of phlorhizin]
|
https://ctdbase.org/detail.go?type=gene&acc=1244
|
||
|
ABCC2
|
Homo sapiens (human)
|
ABCC2 gene polymorphism affects the susceptibility to irinotecan|abcc2 protein results in increased secretion of irinotecan metabolite|abcc2 gene polymorphism affects the susceptibility to irinotecan metabolite|abcc2 protein results in increased secretion of irinotecan
|
https://ctdbase.org/detail.go?type=gene&acc=1244
|
||
|
ABCC2
|
Homo sapiens (human)
|
ABCC2 protein results in decreased susceptibility to irinotecan
|
https://ctdbase.org/detail.go?type=gene&acc=1244
|
||
|
ABCC2
|
Mus musculus (house mouse)
|
ABCC2 gene mutant form results in decreased susceptibility to irinotecan
|
https://ctdbase.org/detail.go?type=gene&acc=1244
|
||
|
ABCC2
|
Homo sapiens (human)
|
ABCC2 protein results in increased export of irinotecan
|
https://ctdbase.org/detail.go?type=gene&acc=1244
|
||
|
ABCC2
|
Danio rerio (zebrafish)
|
Triclosan results in increased expression of ABCC2 mRNA
|
https://ctdbase.org/detail.go?type=gene&acc=1244
|
||
|
ABCC2
|
Homo sapiens (human)
|
Triclosan results in decreased expression of ABCC2 mRNA
|
https://ctdbase.org/detail.go?type=gene&acc=1244
|
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