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Interactions between compounds and specific gene/protein targets.
| BIMP_ID | Target Name | Gene | Organism | Action | Source URL |
|---|---|---|---|---|---|
|
ABCC2
|
Homo sapiens (human)
|
[isopropyl 5,12-hydroxypentadeca-8,10-dien-6,14-diynoate results in decreased activity of ABCC2 protein] which results in increased uptake of vinblastine|[verlukast results in decreased activity of ABCC2 protein] which results in increased uptake of vinblastine
|
https://ctdbase.org/detail.go?type=gene&acc=1244
|
||
|
ABCC2
|
Homo sapiens (human)
|
Probenecid promotes the reaction [ABCC2 protein affects the transport of vinblastine]
|
https://ctdbase.org/detail.go?type=gene&acc=1244
|
||
|
ABCC2
|
Rattus norvegicus (Norway rat)
|
ABCC2 protein results in decreased susceptibility to vinblastine
|
https://ctdbase.org/detail.go?type=gene&acc=1244
|
||
|
ABCC2
|
Homo sapiens (human)
|
Sulfinpyrazone inhibits the reaction [ABCC2 protein results in increased export of vinblastine]|abcc2 protein results in increased export of vinblastine
|
https://ctdbase.org/detail.go?type=gene&acc=1244
|
||
|
ABCC2
|
Mus musculus (house mouse)
|
8-epidiosbulbin E acetate results in decreased expression of ABCC2 mRNA
|
https://ctdbase.org/detail.go?type=gene&acc=1244
|
||
|
ABCC2
|
Homo sapiens (human)
|
Aristolochic acid I results in increased expression of ABCC2 mRNA
|
https://ctdbase.org/detail.go?type=gene&acc=1244
|
||
|
ABCC2
|
Homo sapiens (human)
|
Cholic acid results in increased expression of ABCC2 mRNA
|
https://ctdbase.org/detail.go?type=gene&acc=1244
|
||
|
ABCC2
|
Mus musculus (house mouse)
|
Cholic acid results in increased expression of ABCC2 mRNA
|
https://ctdbase.org/detail.go?type=gene&acc=1244
|
||
|
ABCC2
|
Mus musculus (house mouse)
|
Cholic acid results in increased expression of ABCC2 protein
|
https://ctdbase.org/detail.go?type=gene&acc=1244
|
||
|
ABCC2
|
Homo sapiens (human)
|
[glycochenodeoxycholic acid co-treated with deoxycholic acid co-treated with chenodeoxycholic acid co-treated with glycodeoxycholic acid co-treated with glycocholic acid co-treated with 6-hydroxy-5-((p- sulfophenyl)azo)-2-naphthalenesulfonic acid disodium salt] results in increased expression of ABCC2 mrna|[glycochenodeoxycholic acid co-treated with deoxycholic acid co-treated with chenodeoxycholic acid co-treated with glycodeoxycholic acid co-treated with glycocholic acid co-treated with acetaminophen] results in decreased expression of ABCC2 mrna|[glycochenodeoxycholic acid co-treated with deoxycholic acid co-treated with chenodeoxycholic acid co-treated with glycodeoxycholic acid co-treated with glycocholic acid co-treated with tartrazine] results in decreased expression of ABCC2 mRNA
|
https://ctdbase.org/detail.go?type=gene&acc=1244
|
||
|
ABCC2
|
Mus musculus (house mouse)
|
SLCO1A1 protein affects the susceptibility to [deoxycholic acid affects the expression of ABCC2 mrna]|deoxycholic acid affects the expression of ABCC2 mRNA
|
https://ctdbase.org/detail.go?type=gene&acc=1244
|
||
|
ABCC2
|
Mus musculus (house mouse)
|
[perfluorooctane sulfonic acid co-treated with cellulose] results in increased expression of ABCC2 mRNA
|
https://ctdbase.org/detail.go?type=gene&acc=1244
|
||
|
ABCC2
|
Homo sapiens (human)
|
ABCC2 protein affects the export of phenethyl isothiocyanate|glutathione promotes the reaction [ABCC2 protein affects the export of phenethyl isothiocyanate]
|
https://ctdbase.org/detail.go?type=gene&acc=1244
|
||
|
ABCC2
|
Rattus norvegicus (Norway rat)
|
Acetamide results in decreased expression of ABCC2 mRNA
|
https://ctdbase.org/detail.go?type=gene&acc=1244
|
||
|
ABCC2
|
Mus musculus (house mouse)
|
Chlorogenic acid inhibits the reaction [cisplatin results in increased expression of ABCC2 protein]
|
https://ctdbase.org/detail.go?type=gene&acc=1244
|
||
|
ABCC2
|
Mus musculus (house mouse)
|
PRKAA1 protein affects the reaction [oleanolic acid results in decreased expression of ABCC2 mrna]|dorsomorphin inhibits the reaction [oleanolic acid results in decreased expression of ABCC2 protein]|dorsomorphin inhibits the reaction [oleanolic acid results in decreased expression of ABCC2 mrna]|u 0126 inhibits the reaction [oleanolic acid results in decreased expression of ABCC2 mrna]
|
https://ctdbase.org/detail.go?type=gene&acc=1244
|
||
|
ABCC2
|
Mus musculus (house mouse)
|
GW 4064 inhibits the reaction [oleanolic acid results in decreased expression of ABCC2 mrna]|srt1720 inhibits the reaction [oleanolic acid results in decreased expression of ABCC2 protein]|srt1720 inhibits the reaction [oleanolic acid results in decreased expression of ABCC2 mrna]|hnf1a protein affects the reaction [SRT1720 inhibits the reaction [oleanolic acid results in decreased expression of ABCC2 protein]]|gw 4064 inhibits the reaction [oleanolic acid results in decreased expression of ABCC2 protein]
|
https://ctdbase.org/detail.go?type=gene&acc=1244
|
||
|
ABCC2
|
Mus musculus (house mouse)
|
Oleanolic acid results in decreased expression of ABCC2 mrna|oleanolic acid results in decreased expression of ABCC2 protein
|
https://ctdbase.org/detail.go?type=gene&acc=1244
|
||
|
ABCC2
|
Rattus norvegicus (Norway rat)
|
Abietic acid inhibits the reaction [ABCC2 protein results in increased transport of estradiol-17 beta-glucuronide]
|
https://ctdbase.org/detail.go?type=gene&acc=1244
|
||
|
ABCC2
|
Rattus norvegicus (Norway rat)
|
Taurine results in increased expression of ABCC2 protein
|
https://ctdbase.org/detail.go?type=gene&acc=1244
|
||
|
ABCC2
|
Homo sapiens (human)
|
Triptolide affects the expression of ABCC2 protein|triptolide results in decreased expression of ABCC2 protein
|
https://ctdbase.org/detail.go?type=gene&acc=1244
|
||
|
ABCC2
|
Mus musculus (house mouse)
|
[triptolide co-treated with lipopolysaccharides] results in decreased expression of ABCC2 protein|[triptolide co-treated with lipopolysaccharides co-treated with obeticholic acid] results in increased expression of ABCC2 mrna|[triptolide co-treated with lipopolysaccharides] results in decreased expression of ABCC2 mRNA
|
https://ctdbase.org/detail.go?type=gene&acc=1244
|
||
|
ABCC2
|
Mus musculus (house mouse)
|
[caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with yohimbine co-treated with hydrolyzable tannins] results in increased expression of ABCC2 mRNA
|
https://ctdbase.org/detail.go?type=gene&acc=1244
|
||
|
ABCC2
|
Homo sapiens (human)
|
|
https://www.dgidb.org/genes/hgnc:53
|
||
|
ABCC2
|
Rattus norvegicus (Norway rat)
|
Glycyrrhetinic acid inhibits the reaction [ABCC2 protein results in increased transport of estradiol-17 beta-glucuronide]
|
https://ctdbase.org/detail.go?type=gene&acc=1244
|
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