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Interactions between compounds and specific gene/protein targets.
| BIMP_ID | Target Name | Gene | Organism | Action | Source URL |
|---|---|---|---|---|---|
|
ABCC1
|
Rattus norvegicus (Norway rat)
|
Ursodeoxycholic acid results in increased expression of ABCC1 mRNA
|
https://ctdbase.org/detail.go?type=gene&acc=4363
|
||
|
ABCC1
|
Homo sapiens (human)
|
Epigallocatechin gallate affects the reaction [doxorubicin affects the expression of ABCC1 protein]
|
https://ctdbase.org/detail.go?type=gene&acc=4363
|
||
|
ABCC1
|
Homo sapiens (human)
|
[estradiol results in increased expression of ABCC1 mrna] which results in increased susceptibility to doxorubicin
|
https://ctdbase.org/detail.go?type=gene&acc=4363
|
||
|
ABCC1
|
Homo sapiens (human)
|
Acetylcysteine promotes the reaction [ABCC1 protein results in decreased susceptibility to doxorubicin]|buthionine sulfoximine analog inhibits the reaction [acetylcysteine promotes the reaction [ABCC1 protein results in decreased susceptibility to doxorubicin]]
|
https://ctdbase.org/detail.go?type=gene&acc=4363
|
||
|
ABCC1
|
Homo sapiens (human)
|
Coumarin results in decreased phosphorylation of ABCC1 protein
|
https://ctdbase.org/detail.go?type=gene&acc=4363
|
||
|
ABCC1
|
Macaca fascicularis (crab-eating macaque)
|
ABCC1 protein results in decreased susceptibility to doxorubicin
|
https://ctdbase.org/detail.go?type=gene&acc=4363
|
||
|
ABCC1
|
Homo sapiens (human)
|
Haloperidol inhibits the reaction [ABCC1 protein results in decreased susceptibility to doxorubicin]
|
https://ctdbase.org/detail.go?type=gene&acc=4363
|
||
|
ABCC1
|
Homo sapiens (human)
|
Heparin affects the reaction [ABCC1 protein affects the transport of doxorubicin]
|
https://ctdbase.org/detail.go?type=gene&acc=4363
|
||
|
ABCC1
|
Homo sapiens (human)
|
Indomethacin inhibits the reaction [ABCC1 protein results in decreased susceptibility to doxorubicin]
|
https://ctdbase.org/detail.go?type=gene&acc=4363
|
||
|
ABCC1
|
Homo sapiens (human)
|
GCLC protein inhibits the reaction [ABCC1 protein results in decreased susceptibility to doxorubicin]
|
https://ctdbase.org/detail.go?type=gene&acc=4363
|
||
|
ABCC1
|
Homo sapiens (human)
|
[glycyrrhetinic acid affects the activity of ABCC1 protein] which affects the susceptibility to doxorubicin
|
https://ctdbase.org/detail.go?type=gene&acc=4363
|
||
|
ABCC1
|
Homo sapiens (human)
|
Doxorubicin results in increased expression of ABCC1 protein|doxorubicin promotes the reaction [JUN protein binds to ABCC1 promoter]
|
https://ctdbase.org/detail.go?type=gene&acc=4363
|
||
|
ABCC1
|
Homo sapiens (human)
|
[doxorubicin results in decreased expression of ABCC1 mrna] which results in increased susceptibility to indomethacin
|
https://ctdbase.org/detail.go?type=gene&acc=4363
|
||
|
ABCC1
|
Homo sapiens (human)
|
Doxorubicin results in increased expression of ABCC1 mRNA
|
https://ctdbase.org/detail.go?type=gene&acc=4363
|
||
|
ABCC1
|
Homo sapiens (human)
|
[bortezomib co-treated with doxorubicin] results in decreased expression of ABCC1 protein|[pentoxifylline co-treated with doxorubicin] results in decreased expression of ABCC1 protein|doxorubicin results in decreased expression of ABCC1 protein
|
https://ctdbase.org/detail.go?type=gene&acc=4363
|
||
|
ABCC1
|
Homo sapiens (human)
|
HIF1A protein affects the reaction [[doxorubicin co-treated with IL6 protein] results in increased expression of ABCC1 protein]|[doxorubicin co-treated with IL6 protein] results in increased expression of ABCC1 protein
|
https://ctdbase.org/detail.go?type=gene&acc=4363
|
||
|
ABCC1
|
Homo sapiens (human)
|
Doxorubicin inhibits the reaction [ABCC1 protein affects the transport of vincristine]
|
https://ctdbase.org/detail.go?type=gene&acc=4363
|
||
|
ABCC1
|
Homo sapiens (human)
|
ABCC1 protein results in decreased susceptibility to resveratrol|resveratrol inhibits the reaction [ABCC1 protein results in increased export of S-(2,4-dinitrophenyl)glutathione]|resveratrol promotes the reaction [ABCC1 protein results in increased hydrolysis of adenosine triphosphate]|resveratrol inhibits the reaction [ABCC1 protein results in decreased susceptibility to etoposide]
|
https://ctdbase.org/detail.go?type=gene&acc=4363
|
||
|
ABCC1
|
Homo sapiens (human)
|
[[resveratrol co-treated with doxorubicin] results in decreased expression of ABCC1 mrna] which results in increased uptake of doxorubicin|[resveratrol co-treated with doxorubicin] results in decreased expression of ABCC1 mRNA
|
https://ctdbase.org/detail.go?type=gene&acc=4363
|
||
|
ABCC1
|
Homo sapiens (human)
|
Resveratrol results in decreased expression of ABCC1
|
https://ctdbase.org/detail.go?type=gene&acc=4363
|
||
|
ABCC1
|
Homo sapiens (human)
|
[resveratrol results in decreased expression of ABCC1] which results in increased uptake of doxorubicin
|
https://ctdbase.org/detail.go?type=gene&acc=4363
|
||
|
ABCC1
|
Homo sapiens (human)
|
|
https://www.dgidb.org/genes/hgnc:51
|
||
|
ABCC1
|
Homo sapiens (human)
|
|
https://www.dgidb.org/genes/hgnc:51
|
||
|
ABCC1
|
Homo sapiens (human)
|
N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in increased expression of ABCC1 mRNA
|
https://ctdbase.org/detail.go?type=gene&acc=4363
|
||
|
ABCC1
|
Homo sapiens (human)
|
|
https://www.dgidb.org/genes/hgnc:51
|
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