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Interactions between compounds and specific gene/protein targets.
| BIMP_ID | Target Name | Gene | Organism | Action | Source URL |
|---|---|---|---|---|---|
|
ABCC1
|
Homo sapiens (human)
|
Indomethacin results in decreased expression of ABCC1 mRNA
|
https://ctdbase.org/detail.go?type=gene&acc=4363
|
||
|
ABCC1
|
Mus musculus (house mouse)
|
Indomethacin results in decreased activity of ABCC1 protein
|
https://ctdbase.org/detail.go?type=gene&acc=4363
|
||
|
ABCC1
|
Oryctolagus cuniculus (rabbit)
|
Indomethacin inhibits the reaction [ABCC1 protein results in increased export of fluorescein]|indomethacin inhibits the reaction [ABCC1 protein results in increased export of vincristine]
|
https://ctdbase.org/detail.go?type=gene&acc=4363
|
||
|
ABCC1
|
Rattus norvegicus (Norway rat)
|
Indomethacin results in decreased activity of ABCC1 protein|[indomethacin results in decreased activity of ABCC1 protein] which results in increased uptake of vincristine
|
https://ctdbase.org/detail.go?type=gene&acc=4363
|
||
|
ABCC1
|
Homo sapiens (human)
|
Indomethacin inhibits the reaction [ABCC1 protein results in increased transport of leukotriene c4]|indomethacin inhibits the reaction [ABCC1 protein results in increased transport of eugenol]
|
https://ctdbase.org/detail.go?type=gene&acc=4363
|
||
|
ABCC1
|
Homo sapiens (human)
|
Zidovudine results in increased expression of ABCC1 mRNA
|
https://ctdbase.org/detail.go?type=gene&acc=4363
|
||
|
ABCC1
|
Homo sapiens (human)
|
[[chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with glyphosate] results in decreased susceptibility to temozolomide] which results in increased expression of ABCC1 mrna|[[chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with glyphosate] results in decreased susceptibility to fluorouracil] which results in increased expression of ABCC1 mrna|[[chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with glyphosate] results in decreased susceptibility to cisplatin] which results in increased expression of ABCC1 mRNA
|
https://ctdbase.org/detail.go?type=gene&acc=4363
|
||
|
ABCC1
|
Homo sapiens (human)
|
ABCC1 protein affects the susceptibility to [fluorouracil co-treated with epirubicin co-treated with cyclophosphamide]
|
https://ctdbase.org/detail.go?type=gene&acc=4363
|
||
|
ABCC1
|
Homo sapiens (human)
|
[[chlorpyrifos co-treated with decamethrin co-treated with polymarcine co-treated with glyphosate] results in decreased susceptibility to fluorouracil] which results in increased expression of ABCC1 mRNA
|
https://ctdbase.org/detail.go?type=gene&acc=4363
|
||
|
ABCC1
|
Homo sapiens (human)
|
ABCC1 protein results in increased transport of eugenol|indomethacin inhibits the reaction [ABCC1 protein results in increased transport of eugenol]
|
https://ctdbase.org/detail.go?type=gene&acc=4363
|
||
|
ABCC1
|
Homo sapiens (human)
|
ABCC1 protein results in decreased susceptibility to ethacrynic acid|gstp1 protein promotes the reaction [ABCC1 protein results in decreased susceptibility to ethacrynic acid]
|
https://ctdbase.org/detail.go?type=gene&acc=4363
|
||
|
ABCC1
|
Homo sapiens (human)
|
Glyburide results in decreased activity of ABCC1 protein
|
https://ctdbase.org/detail.go?type=gene&acc=4363
|
||
|
ABCC1
|
Homo sapiens (human)
|
Hypericin results in increased expression of ABCC1 protein
|
https://ctdbase.org/detail.go?type=gene&acc=4363
|
||
|
ABCC1
|
Homo sapiens (human)
|
|
https://www.dgidb.org/genes/hgnc:51
|
||
|
ABCC1
|
Rattus norvegicus (Norway rat)
|
Indole-3-carbinol affects the expression of ABCC1 mRNA
|
https://ctdbase.org/detail.go?type=gene&acc=4363
|
||
|
ABCC1
|
Rattus norvegicus (Norway rat)
|
Indole-3-carbinol results in increased expression of ABCC1 mRNA
|
https://ctdbase.org/detail.go?type=gene&acc=4363
|
||
|
ABCC1
|
Bos taurus (cattle)
|
ABCC1 protein results in decreased susceptibility to etoposide
|
https://ctdbase.org/detail.go?type=gene&acc=4363
|
||
|
ABCC1
|
Canis lupus familiaris (dog)
|
ABCC1 protein results in decreased susceptibility to etoposide
|
https://ctdbase.org/detail.go?type=gene&acc=4363
|
||
|
ABCC1
|
Homo sapiens (human)
|
ABCC1 protein affects the susceptibility to etoposide
|
https://ctdbase.org/detail.go?type=gene&acc=4363
|
||
|
ABCC1
|
Homo sapiens (human)
|
ABCC1 protein results in decreased susceptibility to etoposide
|
https://ctdbase.org/detail.go?type=gene&acc=4363
|
||
|
ABCC1
|
Homo sapiens (human)
|
ABCC1 results in decreased susceptibility to etoposide
|
https://ctdbase.org/detail.go?type=gene&acc=4363
|
||
|
ABCC1
|
Homo sapiens (human)
|
GSTP1 protein promotes the reaction [ABCC1 protein results in decreased susceptibility to etoposide]|[gclc protein co-treated with GCLM protein] promotes the reaction [ABCC1 protein results in decreased susceptibility to etoposide]
|
https://ctdbase.org/detail.go?type=gene&acc=4363
|
||
|
ABCC1
|
Homo sapiens (human)
|
Silymarin inhibits the reaction [ABCC1 protein results in decreased susceptibility to etoposide]|naringenin inhibits the reaction [ABCC1 protein results in decreased susceptibility to etoposide]|hesperetin inhibits the reaction [ABCC1 protein results in decreased susceptibility to etoposide]|resveratrol inhibits the reaction [ABCC1 protein results in decreased susceptibility to etoposide]
|
https://ctdbase.org/detail.go?type=gene&acc=4363
|
||
|
ABCC1
|
Homo sapiens (human)
|
[MYCN protein affects the expression of ABCC1 mrna] which affects the susceptibility to etoposide
|
https://ctdbase.org/detail.go?type=gene&acc=4363
|
||
|
ABCC1
|
Homo sapiens (human)
|
Tocopherols inhibits the reaction [ABCC1 protein affects the export of etoposide]
|
https://ctdbase.org/detail.go?type=gene&acc=4363
|
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