Molecular Targets : Dataset Browser

BIMP_ID	Target Name	Gene	Organism	Action	Source URL
BIMP082880	ABCB1	ABCB1	Homo sapiens (human)	Cyclosporine results in decreased expression of ABCB1 mRNA	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP082880	ABCB1	ABCB1	Homo sapiens (human)	Cyclosporine results in increased expression of ABCB1 mRNA	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP082880	ABCB1	ABCB1	Homo sapiens (human)	Plant extracts affects the reaction [ABCB1 protein results in increased transport of cyclosporine]	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP082880	ABCB1	ABCB1	Ovis aries (sheep)	Cyclosporine inhibits the reaction [ABCB1 results in decreased uptake of digoxin]	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP082880	ABCB1	ABCB1	Rattus norvegicus (Norway rat)	Cyclosporine inhibits the reaction [ABCB1 results in decreased susceptibility to cadmium chloride]	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP082880	ABCB1	ABCB1	Rattus norvegicus (Norway rat)	Cyclosporine results in decreased activity of ABCB1 protein\|[cyclosporine results in decreased activity of ABCB1 protein] which results in increased uptake of carvedilol	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP082880	ABCB1	ABCB1	Rattus norvegicus (Norway rat)	[thioacetamide co-treated with cyclosporine] results in increased expression of ABCB1 mRNA	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP082880	ABCB1	ABCB1	Homo sapiens (human)	Cyclosporine affects the folding of and affects the localization of ABCB1 protein mutant form	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP082880	ABCB1	ABCB1	Homo sapiens (human)	Cyclosporine results in increased activity of ABCB1 protein mutant form\|cyclosporine affects the metabolism of and affects the folding of ABCB1 protein mutant form\|cyclosporine affects the localization of ABCB1 protein mutant form	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP082880	ABCB1	ABCB1	Homo sapiens (human)	Cyclosporine binds to ABCB1 protein	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP082880	ABCB1	ABCB1	Homo sapiens (human)	Cyclosporine inhibits the reaction [ABCB1 protein results in increased export of retrorsine]	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP082880	ABCB1	ABCB1	Homo sapiens (human)	Cyclosporine results in decreased activity of ABCB1 protein	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP082880	ABCB1	ABCB1	Homo sapiens (human)		https://www.dgidb.org/genes/hgnc:40
BIMP090994	ABCB1	ABCB1	Homo sapiens (human)	Disulfiram affects the reaction [ABCB1 protein results in increased hydrolysis of adenosine triphosphate]\|abcb1 protein binds to and results in increased hydrolysis of adenosine triphosphate	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP090994	ABCB1	ABCB1	Homo sapiens (human)	ABCB1 protein results in increased hydrolysis of adenosine triphosphate	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP090994	ABCB1	ABCB1	Homo sapiens (human)	Adenosine triphosphate binds to ABCB1 protein	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP090994	ABCB1	ABCB1	Homo sapiens (human)	Aurapten promotes the reaction [ABCB1 protein results in increased hydrolysis of adenosine triphosphate]\|nobiletin promotes the reaction [ABCB1 protein results in increased hydrolysis of adenosine triphosphate]	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP090994	ABCB1	ABCB1	Homo sapiens (human)	[manganese results in increased activity of ABCB1 protein] which results in increased hydrolysis of adenosine triphosphate\|[magnesium results in increased activity of ABCB1 protein] which results in increased hydrolysis of adenosine triphosphate\|[cobalt results in increased activity of ABCB1 protein] which results in increased hydrolysis of adenosine triphosphate	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP090994	ABCB1	ABCB1	Homo sapiens (human)	Crizotinib promotes the reaction [ABCB1 protein results in increased hydrolysis of adenosine triphosphate]	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP090994	ABCB1	ABCB1	Homo sapiens (human)	Lapatinib promotes the reaction [ABCB1 protein results in increased hydrolysis of adenosine triphosphate]	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP090994	ABCB1	ABCB1	Homo sapiens (human)	Paclitaxel promotes the reaction [ABCB1 protein results in increased hydrolysis of adenosine triphosphate]\|abcb1 protein results in increased hydrolysis of adenosine triphosphate\|vanadates inhibits the reaction [paclitaxel promotes the reaction [ABCB1 protein results in increased hydrolysis of adenosine triphosphate]]	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP090682	ABCB1	ABCB1	Homo sapiens (human)	Ketoconazole inhibits the reaction [spironolactone results in increased expression of ABCB1 protein]\|nr1i2 affects the reaction [spironolactone results in increased expression of ABCB1 protein]\|spironolactone results in increased expression of ABCB1 protein\|spironolactone results in increased expression of ABCB1 mRNA	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP090682	ABCB1	ABCB1	Homo sapiens (human)		https://www.dgidb.org/genes/hgnc:40
BIMP090784	ABCB1	ABCB1	Homo sapiens (human)	ABCB1 protein results in increased export of estrone\|estrone results in increased expression of ABCB1 mrna\|elacridar inhibits the reaction [ABCB1 protein results in increased export of estrone]\|estrone results in increased expression of ABCB1 protein	https://ctdbase.org/detail.go?type=gene&acc=5243
BIMP090784	ABCB1	ABCB1	Homo sapiens (human)	Estrone results in decreased expression of ABCB1 protein	https://ctdbase.org/detail.go?type=gene&acc=5243

BIMP082880

ABCB1

Homo sapiens (human)

Cyclosporine results in decreased expression of ABCB1 mRNA

https://ctdbase.org/detail.go?type=gene&acc=5243

BIMP082880

ABCB1

Homo sapiens (human)

Cyclosporine results in increased expression of ABCB1 mRNA

https://ctdbase.org/detail.go?type=gene&acc=5243

BIMP082880

ABCB1

Homo sapiens (human)

Plant extracts affects the reaction [ABCB1 protein results in increased transport of cyclosporine]

https://ctdbase.org/detail.go?type=gene&acc=5243

BIMP082880

ABCB1

Ovis aries (sheep)

Cyclosporine inhibits the reaction [ABCB1 results in decreased uptake of digoxin]

https://ctdbase.org/detail.go?type=gene&acc=5243

BIMP082880

ABCB1

Rattus norvegicus (Norway rat)

Cyclosporine inhibits the reaction [ABCB1 results in decreased susceptibility to cadmium chloride]

https://ctdbase.org/detail.go?type=gene&acc=5243

BIMP082880

ABCB1

Rattus norvegicus (Norway rat)

Cyclosporine results in decreased activity of ABCB1 protein|[cyclosporine results in decreased activity of ABCB1 protein] which results in increased uptake of carvedilol

https://ctdbase.org/detail.go?type=gene&acc=5243

BIMP082880

ABCB1

Rattus norvegicus (Norway rat)

[thioacetamide co-treated with cyclosporine] results in increased expression of ABCB1 mRNA

https://ctdbase.org/detail.go?type=gene&acc=5243

BIMP082880

ABCB1

Homo sapiens (human)

Cyclosporine affects the folding of and affects the localization of ABCB1 protein mutant form

https://ctdbase.org/detail.go?type=gene&acc=5243

BIMP082880

ABCB1

Homo sapiens (human)

Cyclosporine results in increased activity of ABCB1 protein mutant form|cyclosporine affects the metabolism of and affects the folding of ABCB1 protein mutant form|cyclosporine affects the localization of ABCB1 protein mutant form

https://ctdbase.org/detail.go?type=gene&acc=5243

BIMP082880

ABCB1

Homo sapiens (human)

Cyclosporine binds to ABCB1 protein

https://ctdbase.org/detail.go?type=gene&acc=5243

BIMP082880

ABCB1

Homo sapiens (human)

Cyclosporine inhibits the reaction [ABCB1 protein results in increased export of retrorsine]

https://ctdbase.org/detail.go?type=gene&acc=5243

BIMP082880

ABCB1

Homo sapiens (human)

Cyclosporine results in decreased activity of ABCB1 protein

https://ctdbase.org/detail.go?type=gene&acc=5243

BIMP082880

ABCB1

Homo sapiens (human)

https://www.dgidb.org/genes/hgnc:40

BIMP090994

ABCB1

Homo sapiens (human)

Disulfiram affects the reaction [ABCB1 protein results in increased hydrolysis of adenosine triphosphate]|abcb1 protein binds to and results in increased hydrolysis of adenosine triphosphate

https://ctdbase.org/detail.go?type=gene&acc=5243

BIMP090994

ABCB1

Homo sapiens (human)

ABCB1 protein results in increased hydrolysis of adenosine triphosphate

https://ctdbase.org/detail.go?type=gene&acc=5243

BIMP090994

ABCB1

Homo sapiens (human)

Adenosine triphosphate binds to ABCB1 protein

https://ctdbase.org/detail.go?type=gene&acc=5243

BIMP090994

ABCB1

Homo sapiens (human)

Aurapten promotes the reaction [ABCB1 protein results in increased hydrolysis of adenosine triphosphate]|nobiletin promotes the reaction [ABCB1 protein results in increased hydrolysis of adenosine triphosphate]

https://ctdbase.org/detail.go?type=gene&acc=5243

BIMP090994

ABCB1

Homo sapiens (human)

[manganese results in increased activity of ABCB1 protein] which results in increased hydrolysis of adenosine triphosphate|[magnesium results in increased activity of ABCB1 protein] which results in increased hydrolysis of adenosine triphosphate|[cobalt results in increased activity of ABCB1 protein] which results in increased hydrolysis of adenosine triphosphate

https://ctdbase.org/detail.go?type=gene&acc=5243

BIMP090994

ABCB1

Homo sapiens (human)

Crizotinib promotes the reaction [ABCB1 protein results in increased hydrolysis of adenosine triphosphate]

https://ctdbase.org/detail.go?type=gene&acc=5243

BIMP090994

ABCB1

Homo sapiens (human)

Lapatinib promotes the reaction [ABCB1 protein results in increased hydrolysis of adenosine triphosphate]

https://ctdbase.org/detail.go?type=gene&acc=5243

BIMP090994

ABCB1

Homo sapiens (human)

Paclitaxel promotes the reaction [ABCB1 protein results in increased hydrolysis of adenosine triphosphate]|abcb1 protein results in increased hydrolysis of adenosine triphosphate|vanadates inhibits the reaction [paclitaxel promotes the reaction [ABCB1 protein results in increased hydrolysis of adenosine triphosphate]]

https://ctdbase.org/detail.go?type=gene&acc=5243

BIMP090682

ABCB1

Homo sapiens (human)

Ketoconazole inhibits the reaction [spironolactone results in increased expression of ABCB1 protein]|nr1i2 affects the reaction [spironolactone results in increased expression of ABCB1 protein]|spironolactone results in increased expression of ABCB1 protein|spironolactone results in increased expression of ABCB1 mRNA

https://ctdbase.org/detail.go?type=gene&acc=5243

BIMP090682

ABCB1

Homo sapiens (human)

https://www.dgidb.org/genes/hgnc:40

BIMP090784

ABCB1

Homo sapiens (human)

ABCB1 protein results in increased export of estrone|estrone results in increased expression of ABCB1 mrna|elacridar inhibits the reaction [ABCB1 protein results in increased export of estrone]|estrone results in increased expression of ABCB1 protein

https://ctdbase.org/detail.go?type=gene&acc=5243

BIMP090784

ABCB1

Homo sapiens (human)

Estrone results in decreased expression of ABCB1 protein

https://ctdbase.org/detail.go?type=gene&acc=5243