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Biography

I am currently contributing in the Computational Genomics work at SCFBio, IIT Delhi. My research focuses on understanding genome structure and function using physicochemical DNA features, statistical modeling, and machine learning, with the broader aim of building interpretable and scalable genome annotation frameworks. I am involved in the development of Genome Reader, an all-in-one platform for physicochemical parameter-based annotation of eukaryotic genomes that integrates large-scale data curation, analysis, feature computation, and end-to-end workflows. In parallel, I am working on Prokaryotic Promoter Prediction, where I am adapting our DNA-level biophysical framework to identify promoter regions in bacterial genomes. I am also involved in the conceptualization of an in-house Ayurgenomics pipeline, developing a gene-to-phenotype-to-disease framework that integrates molecular features with constitution-based biological traits to generate hypotheses on disease susceptibility. Recently, I contributed to a large-scale biophysical profiling study that characterized over ~4.6 million genomic sites across multiple eukaryotic kingdoms, spanning coding sequences, promoters, enhancers, untranslated regions (UTRs), codons, and gene boundary elements including exon-intron junctions, gene starts, and gene ends, enabling physics-informed genome annotation. I also contributed to the development of ChemEXIN, a deep-learning-based exon-intron boundary prediction tool built on DNA physicochemical features, part of which originated from my master’s thesis work.

Research Interests

Computational GenomicsMachine Learning/Deep Learning in GenomicsBiophysical ChemistryMulitimodalityMulti-omicsGenetics

Education

Master of Science (Bioinformatics)Jamia Millia Islamia 2021-2023
Bachelor of Science (Life Science)University of Delhi 2018-2021

Selected Publications

Structure and dynamics dictate the functional destiny of genomic DNA across multiple organisms International Journal of Biological Macromolecules 2025 View Paper
Exon-Intron Boundary Detection Made Easy by Physicochemical Properties of DNA Molecular Omics 2025 View Paper
Deep learning in computer-aided drug design: a case study In Deep learning applications in translational bioinformatics (pp. 191-210). Academic Press. Elsevier. 2024 View Paper
The Role of Artificial Intelligence and Machine Learning in Autoimmune Disorders In Artificial intelligence and autoimmune diseases: Applications in the diagnosis, prognosis, and therapeutics (pp. 61-75). Singapore: Springer Nature. 2024 View Paper
DNA Physicochemical Signatures for Prokaryotic Promoter Prediction* In Computational Methods for Molecular Microbiology, Methods in Molecular Biology, Springer Nature. 2026 View Paper
An all-in-one Genome Reader for Eukaryotic Genome Annotation* NA 2026 View Paper