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SCFBio, IIT Delhi Hauz Khas, New Delhi
MOLECULAR TARGET

4-aminobutyrate aminotransferase, mitochondrial

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9

Interactions

Homo sapiens (human)

Organism

ABAT

Gene Name

Compound Associations

S.No BIMP ID Organism Action References
1 BIMP011478 Homo sapiens (human) Inhibitor
2 BIMP011908 Homo sapiens (human) -
3 BIMP011908 Homo sapiens (human) Inhibitor
4 BIMP068132 Homo sapiens (human) -
5 BIMP093282 Homo sapiens (human) Tremorgenic mycotoxins are thought to inhibit gamma-aminobutyric acid (GABA) receptors, both pre- and postsynaptic, as well as inhibit transmitter breakdown at the GABA-T receptors. this would initially increase neurotransmitter levels, potentiating the GABA-induced chloride current, then lead to decreased levels of neurotransmitter in the synapse. (A2976)
6 BIMP093313 Homo sapiens (human) Tremorgenic mycotoxins are thought to inhibit gamma-aminobutyric acid (GABA) receptors, both pre- and postsynaptic, as well as inhibit transmitter breakdown at the GABA-T receptors. this would initially increase neurotransmitter levels, potentiating the GABA-induced chloride current, then lead to decreased levels of neurotransmitter in the synapse. (A2976)
7 BIMP072524 Homo sapiens (human) -
8 BIMP072524 Homo sapiens (human) -
9 BIMP072198 Homo sapiens (human) Valproic acid binds to and inhibits GABA transaminase. the drug's anticonvulsant activity may be related to increased brain concentrations of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter in the CNS, by inhibiting enzymes that catabolize GABA or block the reuptake of GABA into glia and nerve endings. valproic acid may also work by suppressing repetitive neuronal firing through inhibition of voltage-sensitive sodium channels.