SCFBio, IIT Delhi
Hauz Khas, New Delhi
BIMP
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SCFBio, IIT Delhi
Interactions between compounds and specific gene/protein targets.
| BIMP_ID | Target Name | Gene | Organism | Action | Source URL |
|---|---|---|---|---|---|
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Aquifex aeolicus VF5
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https://www.drugbank.ca/bio_entities/BE0001253
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kdsA
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Shigella flexneri
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https://www.drugbank.ca/bio_entities/BE0001394
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Aquifex aeolicus VF5
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https://www.drugbank.ca/bio_entities/BE0001253
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Aquifex aeolicus VF5
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https://www.drugbank.ca/bio_entities/BE0001253
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yniC
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Escherichia coli O157:H7
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https://www.drugbank.ca/bio_entities/BE0001596
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leuA
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Mycobacterium tuberculosis H37Rv
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https://www.drugbank.ca/bio_entities/BE0001742
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prpB
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Escherichia coli K-12
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https://www.drugbank.ca/bio_entities/BE0001259
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OGFOD2
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Homo sapiens (human)
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Cofactor
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https://www.drugbank.ca/bio_entities/BE0002203
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OGDH
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Homo sapiens (human)
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https://www.drugbank.ca/bio_entities/BE0000162
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OGDH
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Homo sapiens (human)
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Inhibitor
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https://www.drugbank.ca/bio_entities/BE0000162
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OGDH
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Homo sapiens (human)
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http://www.t3db.ca/biodb/bio_entities/BE0000162
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Xanthobacter autotrophicus Py2
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https://www.drugbank.ca/bio_entities/BE0001784
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CYP27B1
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Homo sapiens (human)
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http://www.t3db.ca/biodb/bio_entities/BE0000443
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CYP27B1
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Homo sapiens (human)
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http://www.t3db.ca/biodb/bio_entities/BE0000443
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CYP27B1
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Homo sapiens (human)
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The mechanism of action of calcitriol in the treatment of psoriasis is accounted for by their antiproliferative activity for keratinocytes and their stimulation of epidermal cell differentiation. the anticarcinogenic activity of the active form of calcitriol appears to be correlated with cellular vitamin D receptor (VDR) levels. vitamin D receptors belong to the superfamily of steroid-hormone zinc-finger receptors. vdrs selectively bind 1,25(OH)2D and retinoic acid X receptor (RXR) to form a heterodimeric complex that interacts with specific DNA sequences known as vitamin D-responsive elements. vdrs are ligand-activated transcription factors. the receptors activate or repress the transcription of target genes upon binding their respective ligands. it is thought that the anticarcinogenic effect of calcitriol is mediated via vdrs in cancer cells. the immunomodulatory activity of calcitriol is thought to be mediated by vitamin D receptors (vdrs) which are expressed constitutively in monocytes but induced upon activation of T and B lymphocytes. 1,25(OH)2D has also been found to enhance the activity of some vitamin D-receptor positive immune cells and to enhance the sensitivity of certain target cells to various cytokines secreted by immune cells.
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http://www.t3db.ca/biodb/bio_entities/BE0000443
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CYP27B1
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Homo sapiens (human)
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Vitamin D2 is the form of vitamin D most commonly added to foods and nutritional supplements. vitamin D2 must be transformed (hydroxylated) into one of two active forms via the liver or kidney. once transformed, it binds to the vitamin D receptor that then leads to a variety of regulatory roles. vitamin D plays an important role in maintaining calcium balance and in the regulation of parathyroid hormone (PTH). it promotes renal reabsorption of calcium, increases intestinal absorption of calcium and phosphorus, and increases calcium and phosphorus mobilization from bone to plasma. vitamin D2 and its analogs appear to promote intestinal absorption of calcium through binding to a specific receptor in the mucosal cytoplasm of the intestine. subsequently, calcium is absorbed through formation of a calcium-binding protein.
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http://www.t3db.ca/biodb/bio_entities/BE0000443
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CYP27B1
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Homo sapiens (human)
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Substrate
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https://www.drugbank.ca/bio_entities/BE0000443
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CYP27B1
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Homo sapiens (human)
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Substrate
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https://www.drugbank.ca/bio_entities/BE0000443
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CYP27B1
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Homo sapiens (human)
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Calcidiol is transformed in the kidney by 25-hydroxyvitamin D3-1-(alpha)-hydroxylase to calcitriol, the active form of vitamin D3. calcitriol binds to intracellular receptors that then function as transcription factors to modulate gene expression. like the receptors for other steroid hormones and thyroid hormones, the vitamin D receptor has hormone-binding and DNA-binding domains. the vitamin D receptor forms a complex with another intracellular receptor, the retinoid-X receptor, and that heterodimer is what binds to DNA. in most cases studied, the effect is to activate transcription, but situations are also known in which vitamin D suppresses transcription. calcitriol increases the serum calcium concentrations by: increasing GI absorption of phosphorus and calcium, increasing osteoclastic resorption, and increasing distal renal tubular reabsorption of calcium. calcitriol appears to promote intestinal absorption of calcium through binding to the vitamin D receptor in the mucosal cytoplasm of the intestine. subsequently, calcium is absorbed through formation of a calcium-binding protein.
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http://www.t3db.ca/biodb/bio_entities/BE0000443
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CYP27B1
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Homo sapiens (human)
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http://www.t3db.ca/biodb/bio_entities/BE0000443
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2610318N02Rikl
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Rattus norvegicus (Norway rat)
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Bisphenol A results in decreased expression of 2610318N02RIKL mRNA
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https://ctdbase.org/detail.go?type=gene&acc=287935
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2610318N02Rikl
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Rattus norvegicus (Norway rat)
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Dietary sucrose results in increased expression of 2610318N02RIKL mRNA
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https://ctdbase.org/detail.go?type=gene&acc=287935
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PSMC3
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Homo sapiens (human)
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https://www.drugbank.ca/bio_entities/BE0009032
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2700097O09Rikl
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Rattus norvegicus (Norway rat)
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Gentamicins results in increased expression of 2700097O09RIKL mRNA
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https://ctdbase.org/detail.go?type=gene&acc=314128
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28SrRNA-Psi:CR40596
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Drosophila melanogaster (fruit fly)
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Bisphenol A results in decreased expression of 28SRRNA-PSI:CR40596 mRNA
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https://ctdbase.org/detail.go?type=gene&acc=5740740
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No matching records found on this page.